The specific aims of this grant include two total syntheses which are based on aldol chemistry developed in these laboratories three years ago. This methodology utilizes the chemistry of enolate systems arising from vinylogous urethanes. The first of these synthetic targets is the macrolide antibiotic rosaramycin (1), a molecular system of considerable biological interest. Our synthetic effort on this molecule is in its third year. The progress report and first part of the experimental design and methods section of this proposal will discuss the current status of this problem and our intended future efforts on it, respectively. The second part of this proposal involves a construction of the seco-acid of erythromycin (2). In this section, we will propose a detailed study of the methodology we intend to employ for the synthesis along with a description of the synthetic route itself.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI019133-05
Application #
3128531
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1982-09-30
Project End
1988-08-31
Budget Start
1986-09-01
Budget End
1987-08-31
Support Year
5
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of Rochester
Department
Type
Schools of Arts and Sciences
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627