Abstract

Mice are capable of generating cytotoxic T cells which lyse anti-idotype bearing B cell hybridomas. Immunization with anti-idiotypic antibody is another way of generating antigen specific cytotoxic T cells. By fusing antigen specific cells with a muring T cell tumor, immortal cytotoxic T cells which survive without growth factor can be generated. These cytotoxic T hybridomas and growth factor dependent CTL will be used to investigate the development and regulation of T cell immunity. These studies involve an analysis of the control of receptor bearing tumors.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI020541-04
Application #
3130266
Study Section
Immunobiology Study Section (IMB)
Project Start
1984-03-01
Project End
1989-02-28
Budget Start
1987-03-01
Budget End
1989-02-28
Support Year
4
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02115