The objective of this research is to evaluate the fungus Lagenidium giganteum, a pathogen of mosquito larvae, and develop practical methods for its use in the control of mosquitoes which are important vectors of human and livestock diseases. Included are studies on persistence and overwintering in standing water, survival through drying cycles in temporary water and comparisons of methods of introduction (single versus multiple). Experiments will be conducted in natural mosquito breeding sites and in experimental ponds. Field experiments will involve several species of Culex, Aedes and Anopheles mosquitoes in differing types of habitats. Evaluations of the tolerances of different isolates to environmental extremes (temperature, salinity, organic pollution) will be included.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI020886-03
Application #
3130684
Study Section
Tropical Medicine and Parasitology Study Section (TMP)
Project Start
1984-05-01
Project End
1987-04-30
Budget Start
1986-05-01
Budget End
1987-04-30
Support Year
3
Fiscal Year
1986
Total Cost
Indirect Cost
Name
North Carolina State University Raleigh
Department
Type
Earth Sciences/Resources
DUNS #
City
Raleigh
State
NC
Country
United States
Zip Code
27695
Orduz, S; Axtell, R C (1991) Compatibility of Bacillus thuringiensis var. Israelensis and Bacillus sphaericus with the fungal pathogen Lagenidium giganteum (Oomycetes: Lagenidiales). J Am Mosq Control Assoc 7:188-93
Patel, K J; Rueda, L M; Axtell, R C et al. (1991) Temperature-dependent development of the fungal pathogen Lagenidium giganteum (Oomycetes: Lagenidiales) in larvae of Culex quinquefasciatus (Diptera: Culicidae). J Med Entomol 28:95-100
Rueda, L M; Patel, K J; Axtell, R C (1991) Comparison of floating and sinking encapsulated formulations of the fungus Lagenidium giganteum (Oomycetes: Lagenidiales) for control of Anopheles larvae. J Am Mosq Control Assoc 7:250-4
Rueda, L M; Patel, K J; Axtell, R C (1990) Efficacy of encapsulated Lagenidium giganteum (Oomycetes: Lagenidiales) against Culex quinquefasciatus and Aedes aegypti larvae in artificial containers. J Am Mosq Control Assoc 6:694-9
Rueda, L M; Patel, K J; Axtell, R C et al. (1990) Temperature-dependent development and survival rates of Culex quinquefasciatus and Aedes aegypti (Diptera: Culicidae). J Med Entomol 27:892-8
Patel, K J; Rueda, L M; Axtell, R C (1990) Comparisons of different types and concentrations of alginates for encapsulation of Lagenidium giganteum (Oomycetes: Lagenidiales), a fungal pathogen of mosquito larvae. J Am Mosq Control Assoc 6:101-4
Axtell, R C; Guzman, D R (1987) Encapsulation of the mosquito fungal pathogen Lagenidium giganteum (Oomycetes:Lagenidiales) in calcium alginate. J Am Mosq Control Assoc 3:450-9
Guzman, D R; Axtell, R C (1987) Temperature and water quality effects in simulated woodland pools on the infection of Culex mosquito larvae by Lagenidium giganteum (Oomycetes: Lagenidiales) in North Carolina. J Am Mosq Control Assoc 3:211-8
Guzman, D R; Axtell, R C (1987) Population dynamics of Culex quinquefasciatus and the fungal pathogen Lagenidium giganteum (Oomycetes: Lagenidiales) in stagnant water pools. J Am Mosq Control Assoc 3:442-9
Su, X Q; Guzman, D R; Axtell, R C (1986) Factors affecting storage of mycelial cultures of the mosquito fungal pathogen Lagenidium giganteum (Oomycetes: Lagenidiales). J Am Mosq Control Assoc 2:350-4

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