Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
3R01AI022420-10S1
Application #
2003339
Study Section
Immunobiology Study Section (IMB)
Project Start
1985-07-01
Project End
1997-08-31
Budget Start
1996-09-15
Budget End
1997-08-31
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905
Yun, T J; Melvold, R W; Pease, L R (1997) A complex major histocompatibility complex D locus variant generated by an unusual recombination mechanism in mice. Proc Natl Acad Sci U S A 94:1384-9
Vallejo, A N; Pease, L R (1996) The locus-specific enhancer activity of the class I major histocompatibility complex interferon-responsive element is associated with a gamma-interferon (IFN)-inducible factor distinct from STAT1alpha, p48, and IFN regulatory factor-1. J Biol Chem 271:29813-21
Vallejo, A N; Allen, K S; Pease, L R (1995) A common mutation in the hominoid class I A-locus IFN-responsive element results in the loss of enhancer activity. Int Immunol 7:853-9
Vallejo, A N; Pease, L R (1995) Structure of the MHC A and B locus promoters in hominoids. Insights on the evolution of the class I MHC multigene family. J Immunol 154:3912-21
Pullen, J K; Tallquist, M D; Melvold, R W et al. (1994) Recognition of a single amino acid change on the surface of a major transplantation antigen is in the context of self peptide. J Immunol 152:3445-52
Pease, L R; Horton, R M; Pullen, J K et al. (1993) Amino acid changes in the peptide binding site have structural consequences at the surface of class I glycoproteins. J Immunol 150:3375-81
Altintas, A; Cai, Z; Pease, L R et al. (1993) Differential expression of H-2K and H-2D in the central nervous system of mice infected with Theiler's virus. J Immunol 151:2803-12
Hunt, H D; Munitz, T I; Pease, L R (1992) Alloreactive cytotoxic T lymphocytes recognize epitopes determined by both the alpha helices and beta sheets of the class I peptide binding site. J Exp Med 175:821-9
Hildebrand, W H; Horton, R M; Pease, L R et al. (1992) Nucleotide sequence analysis of H-2Df and the spontaneous in vivo H-2Dfm2 mutation. Mol Immunol 29:61-9
Cai, Z; Pease, L R (1992) Structural and functional analysis of three D/L-like class I molecules from H-2v: indications of an ancestral family of D/L genes. J Exp Med 175:583-96

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