Abstract

One of the central problems in modern biology is the control of growth at the cellular level and in the whole organism. The somatomedin/insulin-like growth factor peptides are a group of hormonal peptides with strong structural homology to proinsulin. These peptides have been shown to have growth-promoting actions in many different cell types, and it is proposed that they mediate the growth-promoting actions of growth hormone on the whole body.
The specific aims of this project are to examine the pathophysiology and interrelations of the somatomedin peptides, and to study the synthesis, mode of transport in plasma, interactions with tissue receptor sites, and their biological actions. The study will utilize radioimmunoassays and radioreceptors, synthetic peptides, synthetic oligonucleotide probes, liquid chromatography, electrophoresis. The long term objectives are to clarify the role of the somatomedin peptides in growth control and to fully understand their actions. This work has health-related importance not only for disorders of human growth in childhood, but in other disease conditions where cellular growth control is disturbed such as neoplasia, diabetes, atherosclerosis and aging.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK024085-09
Application #
3227277
Study Section
Endocrinology Study Section (END)
Project Start
1978-12-01
Project End
1988-05-31
Budget Start
1987-06-01
Budget End
1988-05-31
Support Year
9
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Stanford University
Department
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Krieg Jr, R J; Latta, K; Niimi, K et al. (1995) Impact of uraemia on food efficiency and the pulsatile mode of growth hormone secretion in rats. J Endocrinol 146:509-17
Giudice, L C; de Zegher, F; Gargosky, S E et al. (1995) Insulin-like growth factors and their binding proteins in the term and preterm human fetus and neonate with normal and extremes of intrauterine growth. J Clin Endocrinol Metab 80:1548-55
Thabet, M A; Challa, A; Chan, W et al. (1994) Insulin-like growth factor and growth hormone receptor in nephrotic rats. Am J Physiol 266:E102-6
Lamson, G; Giudice, L C; Cohen, P et al. (1993) Proteolysis of IGFBP-3 may be a common regulatory mechanism of IGF action in vivo. Growth Regul 3:91-5
Liu, F; Baker, B K; Powell, D R et al. (1993) Characterization of proinsulin-like growth factor-II E-region immunoreactivity in serum and other biological fluids. J Clin Endocrinol Metab 76:1095-100
Powell, D R; Liu, F; Baker, B et al. (1993) Characterization of insulin-like growth factor binding protein-3 in chronic renal failure serum. Pediatr Res 33:136-43
Challa, A; Chan, W; Krieg Jr, R J et al. (1993) Effect of metabolic acidosis on the expression of insulin-like growth factor and growth hormone receptor. Kidney Int 44:1224-7
Kahn, S E; Horber, F F; Prigeon, R L et al. (1993) Effect of glucocorticoid and growth hormone treatment on proinsulin levels in humans. Diabetes 42:1082-5
De Feo, P; Horber, F F; Haymond, M W (1992) Meal stimulation of albumin synthesis: a significant contributor to whole body protein synthesis in humans. Am J Physiol 263:E794-9
Kirstein, M; Aston, C; Hintz, R et al. (1992) Receptor-specific induction of insulin-like growth factor I in human monocytes by advanced glycosylation end product-modified proteins. J Clin Invest 90:439-46

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