Abstract

Among recent Haitian emigrants living in Miami the prevalence of serum antibodies to HTLV-III/LAV is 2-9%. Haitian-born women deliver between 2200 and 2500 infants annually at Jackson Memorial Hospital in Miami; approximately 20 of these infants will develop clinical evidence of HTLV-III/LAV infection each year. These deliveries constitute at least 90% of all births among Haitian emigrants in Dade County. We propose to determine the proportion of seropositive mothers that give birth to seropositive, virus-positive infants that develop clinical syndromes associated with HTLV-III/LAV infection. Seropositive and seronegative infants of seropositive mothers will be followed with a comparable number of seronegative infants of seronegative mothers for two years to assess their outcome. Information obtained from this population-based study will be of significance in two major areas. First, the information from the mothers will be used to assess the risks to unborn infants of women with HTLV-III/LAV infection. Second, the population-based character of the study will provide more complete information on the clinical spectrum of HTLV-III/LAV infection among infants in this population.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI023524-04
Application #
3135766
Study Section
Epidemiology and Disease Control Subcommittee 3 (EDC)
Project Start
1986-03-01
Project End
1991-02-28
Budget Start
1989-03-01
Budget End
1990-02-28
Support Year
4
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
University of Miami School of Medicine
Department
Type
Schools of Medicine
DUNS #
City
Miami
State
FL
Country
United States
Zip Code
33101

  Publications

Geffin, Rebeca; Hutto, Cecelia; Andrew, Carole et al. (2003) A longitudinal assessment of autologous neutralizing antibodies in children perinatally infected with human immunodeficiency virus type 1. Virology 310:207-15
McCarthy, Micheline; He, Jun; Auger, Denise et al. (2002) Cellular tropisms and co-receptor usage of HIV-1 isolates from vertically infected children with neurological abnormalities and rapid disease progression. J Med Virol 67:1-8
Fletcher, M; Miguez-Burbano, M J; Shor-Posner, G et al. (2000) Diagnosis of human immunodeficiency virus infection using an immunoglobulin E-based assay. Clin Diagn Lab Immunol 7:55-7
Fishkin, P E; Armstrong, F D; Routh, D K et al. (2000) Brief report: relationship between HIV infection and WPPSI-R performance in preschool-age children. J Pediatr Psychol 25:347-51
Jean, S S; Pape, J W; Verdier, R I et al. (1999) The natural history of human immunodeficiency virus 1 infection in Haitian infants. Pediatr Infect Dis J 18:58-63
Armstrong, F D; Harris, L L; Thompson, W et al. (1999) The Outpatient Developmental Services Project: integration of pediatric psychology with primary medical care for children infected with HIV. J Pediatr Psychol 24:381-91
Geffin, R B; Scott, G B; Melenwick, M et al. (1998) Association of antibody reactivity to ELDKWA, a glycoprotein 41 neutralization epitope, with disease progression in children perinatally infected with HIV type 1. AIDS Res Hum Retroviruses 14:579-90
Unal, A; Lorenzo, E; Brown, M et al. (1996) Reverse transcriptase mutations in HIV-1-infected children treated with zidovudine. J Acquir Immune Defic Syndr Hum Retrovirol 13:140-5
McLaughlin, G E; Virdee, S S; Schleien, C L et al. (1995) Effect of corticosteroids on survival of children with acquired immunodeficiency syndrome and Pneumocystis carinii-related respiratory failure. J Pediatr 126:821-4
Gay, C L; Armstrong, F D; Cohen, D et al. (1995) The effects of HIV on cognitive and motor development in children born to HIV-seropositive women with no reported drug use: birth to 24 months. Pediatrics 96:1078-82

Showing the most recent 10 out of 20 publications