Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI023985-02
Application #
3136636
Study Section
Bacteriology and Mycology Subcommittee 1 (BM)
Project Start
1987-06-01
Project End
1990-05-31
Budget Start
1988-06-01
Budget End
1989-05-31
Support Year
2
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of Cincinnati
Department
Type
Schools of Medicine
DUNS #
City
Cincinnati
State
OH
Country
United States
Zip Code
45221

  Publications

Chaturvedi, V; Wong, B; Newman, S L (1996) Oxidative killing of Cryptococcus neoformans by human neutrophils. Evidence that fungal mannitol protects by scavenging reactive oxygen intermediates. J Immunol 156:3836-40
Newman, S L; Chaturvedi, S; Klein, B S (1995) The WI-1 antigen of Blastomyces dermatitidis yeasts mediates binding to human macrophage CD11b/CD18 (CR3) and CD14. J Immunol 154:753-61
Klein, B S; Chaturvedi, S; Hogan, L H et al. (1994) Altered expression of surface protein WI-1 in genetically related strains of Blastomyces dermatitidis that differ in virulence regulates recognition of yeasts by human macrophages. Infect Immun 62:3536-42
Newman, S L; Gootee, L; Brunner, G et al. (1994) Chloroquine induces human macrophage killing of Histoplasma capsulatum by limiting the availability of intracellular iron and is therapeutic in a murine model of histoplasmosis. J Clin Invest 93:1422-9
Newman, S L; Gootee, L; Morris, R et al. (1992) Digestion of Histoplasma capsulatum yeasts by human macrophages. J Immunol 149:574-80
Newman, S L; Mikus, L K; Tucci, M A (1991) Differential requirements for cellular cytoskeleton in human macrophage complement receptor- and Fc receptor-mediated phagocytosis. J Immunol 146:967-74
Newman, S L; Gootee, L; Bucher, C et al. (1991) Inhibition of intracellular growth of Histoplasma capsulatum yeast cells by cytokine-activated human monocytes and macrophages. Infect Immun 59:737-41
Schnur, R A; Newman, S L (1990) The respiratory burst response to Histoplasma capsulatum by human neutrophils. Evidence for intracellular trapping of superoxide anion. J Immunol 144:4765-72
Newman, S L; Bucher, C; Rhodes, J et al. (1990) Phagocytosis of Histoplasma capsulatum yeasts and microconidia by human cultured macrophages and alveolar macrophages. Cellular cytoskeleton requirement for attachment and ingestion. J Clin Invest 85:223-30
Newman, S L; Tucci, M A (1990) Regulation of human monocyte/macrophage function by extracellular matrix. Adherence of monocytes to collagen matrices enhances phagocytosis of opsonized bacteria by activation of complement receptors and enhancement of Fc receptor function. J Clin Invest 86:703-14