The goal of this study is to develop laboratory models to assess the possible role of Chlamydia in human infertility. The general approach will involve studies on the effects of active chlamydial infection or Chlamydia-induced damage on guinea pig and mouse fallopian tube function and intrauterine events. Thus, we will attempt to develop experimental models for acute salpingitis and its chronic sequelae. In addition, we will attempt to study infection of fertilized mouse ova and trophoblast outgrowths and the effects of in vivo and in vitro chlamydial infection on implantation of these ova.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
9R01AI024781-08
Application #
3138011
Study Section
Bacteriology and Mycology Subcommittee 1 (BM)
Project Start
1986-09-30
Project End
1989-08-31
Budget Start
1986-09-30
Budget End
1987-08-31
Support Year
8
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143