Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI024783-06
Application #
2062753
Study Section
Physiology Study Section (PHY)
Project Start
1987-07-01
Project End
1997-08-31
Budget Start
1994-09-01
Budget End
1997-08-31
Support Year
6
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of California Irvine
Department
Physiology
Type
Schools of Medicine
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697
Hanson, D C; Nguyen, A; Mather, R J et al. (1999) UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation. Br J Pharmacol 126:1707-16
Kalman, K; Nguyen, A; Tseng-Crank, J et al. (1998) Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7. J Biol Chem 273:5851-7
Jager, H; Rauer, H; Nguyen, A N et al. (1998) Regulation of mammalian Shaker-related K+ channels: evidence for non-conducting closed and non-conducting inactivated states. J Physiol 506 ( Pt 2):291-301
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Nguyen, A; Kath, J C; Hanson, D C et al. (1996) Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation. Mol Pharmacol 50:1672-9
Wymore, R S; Negulescu, D; Kinoshita, K et al. (1996) Characterization of the transcription unit of mouse Kv1.4, a voltage-gated potassium channel gene. J Biol Chem 271:15629-34
Aiyar, J; Withka, J M; Rizzi, J P et al. (1995) Topology of the pore-region of a K+ channel revealed by the NMR-derived structures of scorpion toxins. Neuron 15:1169-81
Wymore, R S; Korenberg, J R; Kinoshita, K D et al. (1994) Genomic organization, nucleotide sequence, biophysical properties, and localization of the voltage-gated K+ channel gene KCNA4/Kv1.4 to mouse chromosome 2/human 11p14 and mapping of KCNC1/Kv3.1 to mouse 7/human 11p14.3-p15.2 and KCNA1/Kv1.1 to human 12p13 Genomics 20:191-202

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