Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI025185-08
Application #
2062913
Study Section
Immunobiology Study Section (IMB)
Project Start
1987-09-30
Project End
1998-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Wistar Institute
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Pure, E; Cuff, C A (2001) A crucial role for CD44 in inflammation. Trends Mol Med 7:213-21
Li, H L; Davis, W; Pure, E (1999) Suboptimal cross-linking of antigen receptor induces Syk-dependent activation of p70S6 kinase through protein kinase C and phosphoinositol 3-kinase. J Biol Chem 274:9812-20
Noorchashm, H; Bui, A; Li, H L et al. (1999) Characterization of anergic anti-DNA B cells: B cell anergy is a T cell-independent and potentially reversible process. Int Immunol 11:765-76
Li, H L; Davis, W W; Whiteman, E L et al. (1999) The tyrosine kinases Syk and Lyn exert opposing effects on the activation of protein kinase Akt/PKB in B lymphocytes. Proc Natl Acad Sci U S A 96:6890-5
Li, H L; Forman, M S; Kurosaki, T et al. (1997) Syk is required for BCR-mediated activation of p90Rsk, but not p70S6k, via a mitogen-activated protein kinase-independent pathway in B cells. J Biol Chem 272:18200-8
Scheynius, A; Camp, R L; Pure, E (1996) Unresponsiveness to 2,4-dinitro-1-fluoro-benzene after treatment with monoclonal antibodies to leukocyte function-associated molecule-1 and intercellular adhesion molecule-1 during sensitization. J Immunol 156:1804-9
Scheynius, A; Camp, R L; Pure, E (1993) Reduced contact sensitivity reactions in mice treated with monoclonal antibodies to leukocyte function-associated molecule-1 and intercellular adhesion molecule-1. J Immunol 150:655-63
Camp, R L; Scheynius, A; Johansson, C et al. (1993) CD44 is necessary for optimal contact allergic responses but is not required for normal leukocyte extravasation. J Exp Med 178:497-507
Birkeland, M L; Kraus, T; Tardelli, L et al. (1992) Progressive changes in CD45RB phenotype and lymphokine production by murine CD4+ T cells after alloantigen exposure. Immunology 75:632-8
Pure, E; Tardelli, L (1992) Tyrosine phosphorylation is required for ligand-induced internalization of the antigen receptor on B lymphocytes. Proc Natl Acad Sci U S A 89:114-7

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