Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
1R01AI025366-01
Application #
3138849
Study Section
Immunobiology Study Section (IMB)
Project Start
1988-02-01
Project End
1991-01-31
Budget Start
1988-02-01
Budget End
1989-01-31
Support Year
1
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
Schools of Veterinary Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Burkly, L C; Degermann, S; Longley, J et al. (1993) Clonal deletion of V beta 5+ T cells by transgenic I-E restricted to thymic medullary epithelium. J Immunol 151:3954-60
Roth, P E; Doglio, L; Manz, J T et al. (1993) Immunoglobulin gamma 2b transgenes inhibit heavy chain gene rearrangement, but cannot promote B cell development. J Exp Med 178:2007-21
Lo, D; Freedman, J; Hesse, S et al. (1992) Peripheral tolerance to an islet cell-specific hemagglutinin transgene affects both CD4+ and CD8+ T cells. Eur J Immunol 22:1013-22
Lo, D; Pursel, V; Linton, P J et al. (1991) Expression of mouse IgA by transgenic mice, pigs and sheep. Eur J Immunol 21:1001-6
Burkly, L C; Lo, D; Cowing, C et al. (1989) Selective expression of class II E alpha d gene in transgenic mice. J Immunol 142:2081-8
Lo, D; Burkly, L C; Flavell, R A et al. (1989) Tolerance to class II MHC in transgenic mice. Semin Immunol 1:147-53
Lo, D; Burkly, L C; Flavell, R A et al. (1989) Tolerance in transgenic mice expressing class II major histocompatibility complex on pancreatic acinar cells. J Exp Med 170:87-104
Marrack, P; Lo, D; Brinster, R et al. (1988) The effect of thymus environment on T cell development and tolerance. Cell 53:627-34
Lo, D; Burkly, L C; Widera, G et al. (1988) Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells. Cell 53:159-68