This is a longitudinal study of the natural history and intervention outcomes of patients infected with Campylobacter pyloridis (C.p.). The long term objective is the understanding of the possible etiologic role of C.p. in chronic gastritis. In 1988 we will have completed in New Orleans a randomized trial of bismuth subsalicylate vs placebo in chronic active gastritis. This will provide approximately 65 patients positive for Campylabactor (C+) and positive for gastritis (G+). Approximately 15 of these patients will represent failures or recurrances after bismuth therapy. There will also be approximately 35 C- G- patients, representing success of treatment. All patients will be followed up to 2 1/2 years; endoscopy, biopsy, Gram and Warthin Starry stains, cultures and Elisa tests for serum antibody will be performed every 6 months. Forty-three C+ G+ patients will be treated with bismuth subsalicylate and amoxicillin to test if the combined treatment will reduce the rate of relapses. Additionally 43 C+ G+ patients will be treated with sucralfate to test the hypothesis that cytoprotection alone may cure gastritis and clean C.p. from the gastric mucosa. All patients will be asked to respond to an epidemiologic questionnaire directed at pre- infection and pre-relapse events. The spouses of all patients will be asked to give blood for Elisa tests to address the hypothesis of oral transmission. Additionally the prevalance of gastritis in subjects from the Colombian Andes rural area of Narino will be studied to correlate C.p. presence with histology and other parameters.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI025590-02
Application #
3139080
Study Section
Bacteriology and Mycology Subcommittee 1 (BM)
Project Start
1988-05-01
Project End
1991-04-30
Budget Start
1989-05-01
Budget End
1990-04-30
Support Year
2
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Louisiana State University Hsc New Orleans
Department
Type
School of Medicine & Dentistry
DUNS #
782627814
City
New Orleans
State
LA
Country
United States
Zip Code
70112
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Ruiz, B; Rood, J C; Fontham, E T et al. (1994) Vitamin C concentration in gastric juice before and after anti-Helicobacter pylori treatment. Am J Gastroenterol 89:533-9
Brenes, F; Ruiz, B; Correa, P et al. (1993) Helicobacter pylori causes hyperproliferation of the gastric epithelium: pre- and post-eradication indices of proliferating cell nuclear antigen. Am J Gastroenterol 88:1870-5
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