Since 1982, a newly classified bacteria, Campylobacter pyloridis (C. p.) has received a great deal of attention, as to the role it plays as a causative agent in the development of gastroduodenal disease in man. Several clinical studies have confirmed C. p. and its association with gastritis, and in some cases peptic ulcer disease. However, the exact role of C. p. in development of gastroduodenal disease requires further study. In collaboration with scientists at B.U. Medical School, we intend to study select patient populations on a longitudinal basis. Studies are designed to monitor the presence of C. p. in gastric mucosa of patients, over time, by the use of bacterial restriction endonuclease analysis (BRENDA) of C. p. and to monitor host immune response to the infection with ELISA and Western blot methods. In addition, we intend to develop animal model systems that simulate human infection and with these models study the pathogenesis of the disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI025631-03
Application #
3139142
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1988-04-01
Project End
1991-03-31
Budget Start
1990-04-01
Budget End
1991-03-31
Support Year
3
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Type
Other Domestic Higher Education
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Taylor, N S; Hasubski, A T; Fox, J G et al. (1992) Haemagglutination profiles of Helicobacter species that cause gastritis in man and animals. J Med Microbiol 37:299-303
O'Rourke, J; Lee, A; Fox, J G (1992) An ultrastructural study of Helicobacter mustelae and evidence of a specific association with gastric mucosa. J Med Microbiol 36:420-7
Paster, B J; Lee, A; Fox, J G et al. (1991) Phylogeny of Helicobacter felis sp. nov., Helicobacter mustelae, and related bacteria. Int J Syst Bacteriol 41:31-8
Correa, P; Fox, J; Fontham, E et al. (1990) Helicobacter pylori and gastric carcinoma. Serum antibody prevalence in populations with contrasting cancer risks. Cancer 66:2569-74