The goal of this research is to provide a molecular basis for understanding the mechanisms for invasiveness of Candida albicans in AIDS patients. The research will start with the relatively clear fact that C. albicans, must adhere to and colonize cells as a stage in establishing an infection. We will use two approaches: (1) a study of mutants that have lost the ability to adhere to animal cells and are subsequently non-pathogenic, and (2) a study of a germ tube-specific protein as a means of understanding the role germ tube penetration plays in invasiveness. We will use gene cloning techniques to study factors that affect the expression of these properties of invasiveness.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI025788-03
Application #
3139403
Study Section
(SRC)
Project Start
1987-09-30
Project End
1990-08-31
Budget Start
1989-09-01
Budget End
1990-08-31
Support Year
3
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of California Irvine
Department
Type
Schools of Medicine
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697
Sundstrom, P; Irwin, M; Smith, D et al. (1991) Both genes for EF-1 alpha in Candida albicans are translated. Mol Microbiol 5:1703-6
Sundstrom, P; Smith, D; Sypherd, P S (1990) Sequence analysis and expression of the two genes for elongation factor 1 alpha from the dimorphic yeast Candida albicans. J Bacteriol 172:2036-45