The California serogroup viruses have become a serious cause of human disease, especially in the midwestern United States. Although the initial isolation of a member of this group, California Encephalitis, was from California, this group has been little studied in the western United States since that time other than in the central valley of California, and little information is available on the occurrence and public health importance of this important group of mosquito-borne pathogens. Preliminary studies indicate that in addition to California encephalitis, either Jamestown Canyon (JC), a newly emerging human pathogen, or Jerry Slough, a variety of JC originally isolated in California, also occur, especially in high mountain areas of the state. The relationship of JS to JC virus, antigenically and ecologically, is unknown. Northway, a bunyavirus belonging to the Bunyamwera serogroup, also may be a cause of human disease, and has been shown to occur in California as well. We feel that the varied climate and topography of California offers a unique opportunity to study vector relationships of these viruses. Specific objectives of this study are (1) to establish the prevalence of antibodies to California and Bunyamwera serogroup viruses in non-human vertebrates in mountainous areas of California, (2) to incriminate the principal vector species of California and Bunyamwera serogroup viruses in mountainous areas of California, (3) to determine the prevalence of antibodies to California and Bunyamwera serogroup viruses in humans in mountainous areas of California, (4) to document the presence, identity, and geographic and ecological distribution of California and Bunyamwera serogroup viruses in California.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI026154-05
Application #
3139826
Study Section
Tropical Medicine and Parasitology Study Section (TMP)
Project Start
1988-04-01
Project End
1994-03-31
Budget Start
1992-04-01
Budget End
1994-03-31
Support Year
5
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of California Davis
Department
Type
Schools of Earth Sciences/Natur
DUNS #
094878337
City
Davis
State
CA
Country
United States
Zip Code
95618
Fulhorst, C F; Bowen, M D; Hardy, J L et al. (1996) Geographic distribution and serologic and genomic characterization of Morro Bay virus, a newly recognized bunyavirus. Am J Trop Med Hyg 54:563-9
Fulhorst, C F; Hardy, J L; Eldridge, B F et al. (1996) Ecology of Jamestown Canyon virus (Bunyaviridae: California serogroup) in coastal California. Am J Trop Med Hyg 55:185-9
Bowen, M D; Jackson, A O; Bruns, T D et al. (1995) Determination and comparative analysis of the small RNA genomic sequences of California encephalitis, Jamestown Canyon, Jerry Slough, Melao, Keystone and Trivittatus viruses (Bunyaviridae, genus Bunyavirus, California serogroup). J Gen Virol 76 ( Pt 3):559-72
Fulhorst, C F; Hardy, J L; Eldridge, B F et al. (1994) Natural vertical transmission of western equine encephalomyelitis virus in mosquitoes. Science 263:676-8
Reeves, W C; Hardy, J L; Reisen, W K et al. (1994) Potential effect of global warming on mosquito-borne arboviruses. J Med Entomol 31:323-32
Kramer, L D; Hardy, J L; Reeves, W C et al. (1993) Vector competence of selected mosquito species (Diptera: Culicidae) for California strains of Northway virus (Bunyaviridae: Bunyavirus). J Med Entomol 30:607-13
Hardy, J L; Eldridge, B F; Reeves, W C et al. (1993) Isolations of Jamestown canyon virus (Bunyaviridae: California serogroup) from mosquitoes (Diptera: Culicidae) in the western United States, 1990-1992. J Med Entomol 30:1053-9
Kramer, L D; Bowen, M D; Hardy, J L et al. (1993) Vector competence of alpine, Central Valley, and coastal mosquitoes (Diptera: Culicidae) from California for Jamestown Canyon virus. J Med Entomol 30:398-406
Kramer, L D; Reeves, W C; Hardy, J L et al. (1992) Vector competence of California mosquitoes for California encephalitis and California encephalitis-like viruses. Am J Trop Med Hyg 47:562-73
Campbell, G L; Reeves, W C; Hardy, J L et al. (1992) Seroepidemiology of California and Bunyamwera serogroup bunyavirus infections in humans in California. Am J Epidemiol 136:308-19

Showing the most recent 10 out of 17 publications