Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI026689-08
Application #
2063493
Study Section
Immunological Sciences Study Section (IMS)
Project Start
1989-04-01
Project End
1997-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Yale University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Szczepanik, M; Lewis, J; Geba, G P et al. (1998) Positive regulatory gamma delta T cells in contact sensitivity: augmented responses by in vivo treatment with anti-gamma delta monoclonal antibody, or anti-V gamma 5 or V delta 4. Immunol Invest 27:1-15
Ushio, H; Tsuji, R F; Szczepanik, M et al. (1998) IL-12 reverses established antigen-specific tolerance of contact sensitivity by affecting costimulatory molecules B7-1 (CD80) and B7-2 (CD86). J Immunol 160:2080-8
Ptak, W; Paliwal, V; Bryniarski, K et al. (1998) Aggregated immunoglobulin protects immune T cells from suppression: dependence on isotype, Fc portion, and macrophage FcgammaR. Scand J Immunol 47:136-45
Szczepanik, M; Nowak, B; Askenase, P W et al. (1998) Cross-talk between gammadelta T lymphocytes and immune cells in humoral response. Immunology 95:612-7
Murray, A G; Schechner, J S; Epperson, D E et al. (1998) Dermal microvascular injury in the human peripheral blood lymphocyte reconstituted-severe combined immunodeficient (HuPBL-SCID) mouse/skin allograft model is T cell mediated and inhibited by a combination of cyclosporine and rapamycin. Am J Pathol 153:627-38
Szczepanik, M; Anderson, L R; Ushio, H et al. (1997) Gamma/delta T cells from tolerized alpha/beta-TCR-deficient mice antigen specifically inhibit contact sensitivity in vivo and IFN-gamma production in vitro. Int Arch Allergy Immunol 113:373-5
Matsuda, H; Ushio, H; Geba, G P et al. (1997) Human platelets can initiate T cell-dependent contact sensitivity through local serotonin release mediated by IgE antibodies. J Immunol 158:2891-7
Tsuji, R F; Geba, G P; Wang, Y et al. (1997) Required early complement activation in contact sensitivity with generation of local C5-dependent chemotactic activity, and late T cell interferon gamma: a possible initiating role of B cells. J Exp Med 186:1015-26
Paliwal, V; Ptak, W; Sperl, J et al. (1997) Recombinant soluble alphabeta T cell receptors protect T cells from immune suppression: requirement for aggregated multimeric, disulfide-linked alphabeta heterodimers. J Immunol 159:1718-27
Ptak, W; Szczepanik, M; Ramabhadran, R et al. (1996) Immune or normal gamma delta T cells that assist alpha beta T cells in elicitation of contact sensitivity preferentially use V gamma 5 and V delta 4 variable region gene segments. J Immunol 156:976-86

Showing the most recent 10 out of 30 publications