Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI026827-09
Application #
2063572
Study Section
Immunobiology Study Section (IMB)
Project Start
1988-07-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239
Whitcomb, Elizabeth A; Martin, Tammy M; Rittenberg, Marvin B (2003) Restoration of Ig secretion: mutation of germline-encoded residues in T15L chains leads to secretion of free light chains and assembled antibody complexes bearing secretion-impaired heavy chains. J Immunol 170:1903-9
Wiens, Gregory D; Brown, McKay; Rittenberg, Marvin B (2003) Repertoire shift in the humoral response to phosphocholine-keyhole limpet hemocyanin: VH somatic mutation in germinal center B cells impairs T15 Ig function. J Immunol 170:5095-102
Wiens, G D; O'Hare, T; Rittenberg, M B (2001) Recovering antibody secretion using a hapten ligand as a chemical chaperone. J Biol Chem 276:40933-9
Wiens, G D; Lekkerkerker, A; Veltman, I et al. (2001) Mutation of a single conserved residue in VH complementarity-determining region 2 results in a severe Ig secretion defect. J Immunol 167:2179-86
Brown, M; Schumacher, M A; Wiens, G D et al. (2000) The structural basis of repertoire shift in an immune response to phosphocholine. J Exp Med 191:2101-12
Brown, M; Wiens, G D; O'Hare, T et al. (1999) Replacements in the exposed loop of the T15 antibody VH CDR2 affect carrier recognition of PC-containing pathogens. Mol Immunol 36:205-11
O'Hare, T; Wiens, G D; Whitcomb, E A et al. (1999) Cutting edge: proteasome involvement in the degradation of unassembled Ig light chains. J Immunol 163:11-4
Wiens, G D; Roberts, V A; Whitcomb, E A et al. (1998) Harmful somatic mutations: lessons from the dark side. Immunol Rev 162:197-209
Martin, T M; Wiens, G D; Rittenberg, M B (1998) Inefficient assembly and intracellular accumulation of antibodies with mutations in V(H) CDR2. J Immunol 160:5963-70
Heldwein, K A; Duncan, J E; Stenzel, P et al. (1997) Endotoxin regulates corticotropin-releasing hormone receptor 2 in heart and skeletal muscle. Mol Cell Endocrinol 131:167-72

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