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Robbins, B L; Greenhaw, J; Fridland, A (2000) Cellular phosphorylation of 2',3'-dideoxyadenosine-5'-monophosphate, a key intermediate in the activation of the antiviral agent DDI, in human peripheral blood mononuclear cells. Nucleosides Nucleotides Nucleic Acids 19:405-13
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Srinivas, R V; Fridland, A (1998) Antiviral activities of 9-R-2-phosphonomethoxypropyl adenine (PMPA) and bis(isopropyloxymethylcarbonyl)PMPA against various drug-resistant human immunodeficiency virus strains. Antimicrob Agents Chemother 42:1484-7
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Robbins, B L; Srinivas, R V; Kim, C et al. (1998) Anti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug of the acyclic nucleoside phosphonate 9-R-(2-phosphonomethoxypropyl)adenine (PMPA), Bis(isopropyloxymethylcarbonyl)PMPA. Antimicrob Agents Chemother 42:612-7
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Robbins, B L; Tran, T T; Pinkerton Jr, F H et al. (1998) Development of a new cartridge radioimmunoassay for determination of intracellular levels of lamivudine triphosphate in the peripheral blood mononuclear cells of human immunodeficiency virus-infected patients. Antimicrob Agents Chemother 42:2656-60
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Srinivas, R V; Middlemas, D; Flynn, P et al. (1998) Human immunodeficiency virus protease inhibitors serve as substrates for multidrug transporter proteins MDR1 and MRP1 but retain antiviral efficacy in cell lines expressing these transporters. Antimicrob Agents Chemother 42:3157-62
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Tanaka, M; Srinivas, R V; Ueno, T et al. (1997) In vitro induction of human immunodeficiency virus type 1 variants resistant to 2'-beta-Fluoro-2',3'-dideoxyadenosine. Antimicrob Agents Chemother 41:1313-8
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Srinivas, R V; Connely, M; Fridland, A (1997) (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) inhibits HIV-1 replication in epithelial cells, but not T-lymphocytes. Antiviral Res 35:23-7
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Robbins, B L; Waibel, B H; Fridland, A (1996) Quantitation of intracellular zidovudine phosphates by use of combined cartridge-radioimmunoassay methodology. Antimicrob Agents Chemother 40:2651-4
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Robbins, B L; Greenhaw, J; Connelly, M C et al. (1995) Metabolic pathways for activation of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine in human lymphoid cells. Antimicrob Agents Chemother 39:2304-8
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Robbins, B L; Connelly, M C; Marshall, D R et al. (1995) A human T lymphoid cell variant resistant to the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl)adenine shows a unique combination of a phosphorylation defect and increased efflux of the agent. Mol Pharmacol 47:391-7
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