Abstract

The infection of infants with AIDS generally occurs ante-or intra- partum. The logical approach to the prevention or reduction in the severity of infection is to treat the infected mother. The therapeutic agents that are currently under consideration for such use are nucleosides. It would be highly desirable to know the potential of exposure of the fetus to these agents while treating the mother. It is proposed to study in a perfusion system of human placenta the transfer and metabolism of AZT and dideoxyadenosine. Thymidine and adenosine, from which these and possible future drugs are derived, will also be studied. Efficient nucleoside transport systems have been described in cells from a variety of sources. Nothing is known about the human placenta.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI028256-03
Application #
3142625
Study Section
Special Emphasis Panel (ARR (V1))
Project Start
1989-05-01
Project End
1992-04-30
Budget Start
1991-05-01
Budget End
1992-04-30
Support Year
3
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
New York University
Department
Type
Schools of Medicine
DUNS #
004514360
City
New York
State
NY
Country
United States
Zip Code
10012

  Publications

Dancis, J; Lee, J; Mendoza, S et al. (1993) Nucleoside transport by perfused human placenta. Placenta 14:547-54
Liebes, L; Mendoza, S; Lee, J D et al. (1993) Further observations on zidovudine transfer and metabolism by human placenta. AIDS 7:590-2
Liebes, L; Mendoza, S; Wilson, D et al. (1990) Transfer of zidovudine (AZT) by human placenta. J Infect Dis 161:203-7