Abstract

The investigator has two specific aims. The first is to study genetic diversity and phylogeny among naturally-occurring SIVs from African non-human primates. The author will attempt to more rigorously define viral evolution and divergence of SIVagm (SIV in African Green Monkeys) viruses in relation to their host species. Full-length clones of SIVagm(sab) from West African green monkeys and SIVagm(tan) from tantalus monkeys will be sequenced and compared with two other species of African green monkeys (vervet and grivets). Additional SIVagm (gri) and SIVabm(ver) viruses will be analyzed to determine whether species-specific SIVagm viruses from vervet, grivet, sabaeus and tantalus monkeys have evolved and diverged coincident with their respective host species. In addition, the author will expand genetic studies to include viruses from other monkey species within the Cercopithecus genus, including Patas and Hamlyn's monkeys. The second goal of the investigator is to define and compare viral and host determinants of pathogenesis for naturally-occurring SIVs. The purpose of this aim is to define viral and host factors which play a role in determining natural resistance to disease. Certain strains of SIVagm may be more pathogenic than others. The study of more pathogenic strains of SIVagm strains may lead to the identification of specific determinants directly involved in pathogenesis. Both molecular and biologic clones derived from green monkeys with SIV-related abnormalities will be further studied in the green monkey animal model.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
2R01AI028273-04
Application #
3142659
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Project Start
1989-03-01
Project End
1997-02-28
Budget Start
1992-03-01
Budget End
1993-02-28
Support Year
4
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
Southwest Foundation for Biomedical Research
Department
Type
DUNS #
City
San Antonio
State
TX
Country
United States
Zip Code
78245

  Publications

Sanders-Beer, Brigitte E; Eschricht, Magdalena; Seifried, Janna et al. (2012) Characterization of a monoclonal anti-capsid antibody that cross-reacts with three major primate lentivirus lineages. Virology 422:402-12
Broussard, S R; Staprans, S I; White, R et al. (2001) Simian immunodeficiency virus replicates to high levels in naturally infected African green monkeys without inducing immunologic or neurologic disease. J Virol 75:2262-75
Allan, J S; Broussard, S R; Michaels, M G et al. (1998) Amplification of simian retroviral sequences from human recipients of baboon liver transplants. AIDS Res Hum Retroviruses 14:821-4
Soares, M A; Robertson, D L; Hui, H et al. (1997) A full-length and replication-competent proviral clone of SIVAGM from tantalus monkeys. Virology 228:394-9
Broussard, S R; Comuzzie, A G; Leighton, K L et al. (1997) Characterization of new simian foamy viruses from African nonhuman primates. Virology 237:349-59
Jolly CJoff; Phillips-Conroy, J E; Turner, T R et al. (1996) SIVagm incidence over two decades in a natural population of Ethiopian grivet monkeys (Cercopithecus aethiops aethiops). J Med Primatol 25:78-83
Robertson, D L; Hahn, B H; Sharp, P M (1995) Recombination in AIDS viruses. J Mol Evol 40:249-59
Sharp, P M; Robertson, D L; Hahn, B H (1995) Cross-species transmission and recombination of 'AIDS' viruses. Philos Trans R Soc Lond B Biol Sci 349:41-7
Jin, M J; Rogers, J; Phillips-Conroy, J E et al. (1994) Infection of a yellow baboon with simian immunodeficiency virus from African green monkeys: evidence for cross-species transmission in the wild. J Virol 68:8454-60
Phillips-Conroy, J E; Jolly, C J; Petros, B et al. (1994) Sexual transmission of SIVagm in wild grivet monkeys. J Med Primatol 23:1-7

Showing the most recent 10 out of 16 publications