RNA/DNA Hybrid Binding Agents

Takusagawa, Fusao None

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project (R01)
• Project #: 5R01AI028578-03
• Application #: 2064550
• Study Section: AIDS and Related Research Study Section 4 (ARRD)
• Project Start: 1992-07-01
• Project End: 1997-06-30
• Budget Start: 1994-07-01
• Budget End: 1997-06-30
• Support Year: 3
• Fiscal Year: 1994

Institution

• Name: University of Kansas Lawrence
• Department: Chemistry
• Type: Schools of Arts and Sciences
• DUNS #: 072933393
• City: Lawrence
• State: KS
• Country: United States
• Zip Code: 66045

Publications

Takusagawa, F; Takusagawa, K T; Carlson, R G et al. (1997) Selectivity of F8-actinomycin D for RNA:DNA hybrids and its anti-leukemia activity. Bioorg Med Chem 5:1197-207

Takusagawa, F; Wen, L; Chu, W et al. (1996) Physical and biological characteristics of the antitumor drug actinomycin D analogues derivatized at N-methyl-L-valine residues. Biochemistry 35:13240-9

Shinomiya, M; Chu, W; Carlson, R G et al. (1995) Structural, physical, and biological characteristics of RNA.DNA binding agent N8-actinomycin D. Biochemistry 34:8481-91