Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI028760-07
Application #
2064599
Study Section
AIDS and Related Research Study Section 4 (ARRD)
Project Start
1989-09-30
Project End
1997-04-30
Budget Start
1995-05-01
Budget End
1997-04-30
Support Year
7
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Bickel, U; Yoshikawa, T; Pardridge, W M (2001) Delivery of peptides and proteins through the blood-brain barrier. Adv Drug Deliv Rev 46:247-79
Wu, D; Boado, R J; Pardridge, W M (1996) Pharmacokinetics and blood-brain barrier transport of [3H]-biotinylated phosphorothioate oligodeoxynucleotide conjugated to a vector-mediated drug delivery system. J Pharmacol Exp Ther 276:206-11
Walus, L R; Pardridge, W M; Starzyk, R M et al. (1996) Enhanced uptake of rsCD4 across the rodent and primate blood-brain barrier after conjugation to anti-transferrin receptor antibodies. J Pharmacol Exp Ther 277:1067-75
Pardridge, W M; Kang, Y S; Diagne, A et al. (1996) Cationized hyperimmune immunoglobulins: pharmacokinetics, toxicity evaluation and treatment of human immunodeficiency virus-infected human-peripheral blood lymphocytes-severe combined immune deficiency mice. J Pharmacol Exp Ther 276:246-52
Wu, D; Pardridge, W M (1996) Central nervous system pharmacologic effect in conscious rats after intravenous injection of a biotinylated vasoactive intestinal peptide analog coupled to a blood-brain barrier drug delivery system. J Pharmacol Exp Ther 279:77-83
Kang, Y S; Boado, R J; Pardridge, W M (1995) Pharmacokinetics and organ clearance of a 3'-biotinylated, internally [32P]-labeled phosphodiester oligodeoxynucleotide coupled to a neutral avidin/monoclonal antibody conjugate. Drug Metab Dispos 23:55-9
Boado, R J; Kang, Y S; Wu, D et al. (1995) Rapid plasma clearance and metabolism in vivo of a phosphorothioate oligodeoxynucleotide with a single, internal phosphodiester bond. Drug Metab Dispos 23:1297-300
Pardridge, W M; Boado, R J; Kang, Y S (1995) Vector-mediated delivery of a polyamide (""peptide"") nucleic acid analogue through the blood-brain barrier in vivo. Proc Natl Acad Sci U S A 92:5592-6
Skarlatos, S; Yoshikawa, T; Pardridge, W M (1995) Transport of [125I]transferrin through the rat blood-brain barrier. Brain Res 683:164-71
Skarlatos, S; Pardridge, W M (1995) Targeting of an anti-CR3 (CD11b/CD18) monoclonal antibody to spleen but not brain, in vivo in mice. J Drug Target 3:9-14

Showing the most recent 10 out of 30 publications