Attenuated Salmonella as Vaccine Vectors

Clements, John D.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project (R01)
• Project #: 5R01AI028835-07
• Application #: 2064661
• Study Section: Bacteriology and Mycology Subcommittee 2 (BM)
• Project Start: 1990-07-01
• Project End: 1998-06-30
• Budget Start: 1996-07-01
• Budget End: 1997-06-30
• Support Year: 7
• Fiscal Year: 1996

Institution

• Name: Tulane University
• Department: Microbiology/Immun/Virology
• Type: Schools of Medicine
• City: New Orleans
• State: LA
• Country: United States
• Zip Code: 70118

Publications

Ryan, E T; Crean, T I; John, M et al. (1999) In vivo expression and immunoadjuvancy of a mutant of heat-labile enterotoxin of Escherichia coli in vaccine and vector strains of Vibrio cholerae. Infect Immun 67:1694-701

Freytag, L C; Clements, J D (1999) Bacterial toxins as mucosal adjuvants. Curr Top Microbiol Immunol 236:215-36

Chong, C; Friberg, M; Clements, J D (1998) LT(R192G), a non-toxic mutant of the heat-labile enterotoxin of Escherichia coli, elicits enhanced humoral and cellular immune responses associated with protection against lethal oral challenge with Salmonella spp. Vaccine 16:732-40

Toebe, C S; Clements, J D; Cardenas, L et al. (1997) Evaluation of immunogenicity of an oral Salmonella vaccine expressing recombinant Plasmodium berghei merozoite surface protein-1. Am J Trop Med Hyg 56:192-9

Bost, K L; Clements, J D (1997) Intracellular Salmonella dublin induces substantial secretion of the 40-kilodalton subunit of interleukin-12 (IL-12) but minimal secretion of IL-12 as a 70-kilodalton protein in murine macrophages. Infect Immun 65:3186-92

Guidry, J J; Cardenas, L; Cheng, E et al. (1997) Role of receptor binding in toxicity, immunogenicity, and adjuvanticity of Escherichia coli heat-labile enterotoxin. Infect Immun 65:4943-50

Chong, C; Bost, K L; Clements, J D (1996) Differential production of interleukin-12 mRNA by murine macrophages in response to viable or killed Salmonella spp. Infect Immun 64:1154-60

Bost, K L; Holton, R H; Cain, T K et al. (1996) In vivo treatment with anti-interleukin-13 antibodies significantly reduces the humoral immune response against an oral immunogen in mice. Immunology 87:633-41

Kincy-Cain, T; Clements, J D; Bost, K L (1996) Endogenous and exogenous interleukin-12 augment the protective immune response in mice orally challenged with Salmonella dublin. Infect Immun 64:1437-40

Bost, K L; Clements, J D (1995) In vivo induction of interleukin-12 mRNA expression after oral immunization with Salmonella dublin or the B subunit of Escherichia coli heat-labile enterotoxin. Infect Immun 63:1076-83