Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
2R01AI028944-05A3
Application #
2064742
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1990-05-01
Project End
2001-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Yale University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Kalia, Awdhesh; Bessen, Debra E (2004) Natural selection and evolution of streptococcal virulence genes involved in tissue-specific adaptations. J Bacteriol 186:110-21
Kalia, Awdhesh; Bessen, Debra E (2003) Presence of streptococcal pyrogenic exotoxin A and C genes in human isolates of group G streptococci. FEMS Microbiol Lett 219:291-5
Svensson, Mikael D; Sjobring, Ulf; Luo, Feng et al. (2002) Roles of the plasminogen activator streptokinase and the plasminogen-associated M protein in an experimental model for streptococcal impetigo. Microbiology 148:3933-45
Kalia, Awdhesh; Spratt, Brian G; Enright, Mark C et al. (2002) Influence of recombination and niche separation on the population genetic structure of the pathogen Streptococcus pyogenes. Infect Immun 70:1971-83
Bessen, Debra E; Kalia, Awdhesh (2002) Genomic localization of a T serotype locus to a recombinatorial zone encoding extracellular matrix-binding proteins in Streptococcus pyogenes. Infect Immun 70:1159-67
Kalia, A; Enright, M C; Spratt, B G et al. (2001) Directional gene movement from human-pathogenic to commensal-like streptococci. Infect Immun 69:4858-69
Enright, M C; Spratt, B G; Kalia, A et al. (2001) Multilocus sequence typing of Streptococcus pyogenes and the relationships between emm type and clone. Infect Immun 69:2416-27
Scaramuzzino, D A; McNiff, J M; Bessen, D E (2000) Humanized in vivo model for streptococcal impetigo. Infect Immun 68:2880-7
Bessen, D E; Carapetis, J R; Beall, B et al. (2000) Contrasting molecular epidemiology of group A streptococci causing tropical and nontropical infections of the skin and throat. J Infect Dis 182:1109-16
Svensson, M D; Scaramuzzino, D A; Sjobring, U et al. (2000) Role for a secreted cysteine proteinase in the establishment of host tissue tropism by group A streptococci. Mol Microbiol 38:242-53

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