Human immunodeficiency virus type 1 (HIV-1) exhibits a long clinical latent period between infection of individuals and the first evidence of disease. Unlike most other animal retroviruses, infection by HIV-1 does not result in high viremia and virus production in vivo. This suggests that the establishment of latent states in infected cells may be important in HIV-1 pathogenesis. In this proposal, in vitro HIV-1 persistence/latency will be investigated. Model systems will be developed, using primary human T-lymphocytes and a molecularly cloned primary isolate of HIV-1. These models will be used in conjunction with highly sensitive molecular techniques to investigate the molecular nature of HIV-1 in the latent state and following reactivation. These studies will allow the development of new assays and the understanding of viral targets for potential therapeutic agents.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI029107-02
Application #
3143807
Study Section
Special Emphasis Panel (ARR (V3))
Project Start
1989-09-30
Project End
1994-07-31
Budget Start
1990-08-01
Budget End
1991-07-31
Support Year
2
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095