Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
3R01AI029200-05S1
Application #
2064878
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Project Start
1990-12-01
Project End
1997-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Saint Louis University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
City
Saint Louis
State
MO
Country
United States
Zip Code
63103
Kamine, J; Elangovan, B; Subramanian, T et al. (1996) Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 Tat transactivator. Virology 216:357-66
Venkatesh, L K; Yang, C; Theodorakis, P A et al. (1993) Functional dissection of the human spumaretrovirus transactivator identifies distinct classes of dominant-negative mutants. J Virol 67:161-9
Kamine, J; Subramanian, T; Chinnadurai, G (1993) Activation of a heterologous promoter by human immunodeficiency virus type 1 Tat requires Sp1 and is distinct from the mode of activation by acidic transcriptional activators. J Virol 67:6828-34
Venkatesh, L K; Chinnadurai, G (1993) The carboxy-terminal transcription enhancement region of the human spumaretrovirus transactivator contains discrete determinants of the activator function. J Virol 67:3868-76
Subramanian, T; Chinnadurai, G (1992) A high-level expression vector for human cells. Gene 120:287-9
Elangovan, B; Subramanian, T; Chinnadurai, G (1992) Functional comparison of the basic domains of the Tat proteins of human immunodeficiency virus types 1 and 2 in trans activation. J Virol 66:2031-6
Kamine, J; Chinnadurai, G (1992) Synergistic activation of the human immunodeficiency virus type 1 promoter by the viral Tat protein and cellular transcription factor Sp1. J Virol 66:3932-6
Subramanian, T; Govindarajan, R; Chinnadurai, G (1991) Heterologous basic domain substitutions in the HIV-1 Tat protein reveal an arginine-rich motif required for transactivation. EMBO J 10:2311-8
Chinnadurai, G (1991) Modulation of HIV-enhancer activity by heterologous agents: a minireview. Gene 101:165-70
Kamine, J; Subramanian, T; Chinnadurai, G (1991) Sp1-dependent activation of a synthetic promoter by human immunodeficiency virus type 1 Tat protein. Proc Natl Acad Sci U S A 88:8510-4