Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI029385-06
Application #
2064962
Study Section
Immunobiology Study Section (IMB)
Project Start
1991-04-01
Project End
1997-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Walter and Eliza Hall Institute Medical Research
Department
Type
DUNS #
City
Victoria
State
Country
Australia
Zip Code
VIC, -3052
Heath, W R; Kurts, C; Miller, J F et al. (1998) Cross-tolerance: a pathway for inducing tolerance to peripheral tissue antigens. J Exp Med 187:1549-53
Allison, J; Stephens, L A; Kay, T W et al. (1998) The threshold for autoimmune T cell killing is influenced by B7-1. Eur J Immunol 28:949-60
Kurts, C; Miller, J F; Subramaniam, R M et al. (1998) Major histocompatibility complex class I-restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction. J Exp Med 188:409-14
Koniaras, C; Heath, W R; Lew, A M (1998) T cell unresponsiveness in vitro can be due to activation in vivo. Int Immunol 10:365-9
Barnden, M J; Allison, J; Heath, W R et al. (1998) Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements. Immunol Cell Biol 76:34-40
Kurts, C; Heath, W R; Kosaka, H et al. (1998) The peripheral deletion of autoreactive CD8+ T cells induced by cross-presentation of self-antigens involves signaling through CD95 (Fas, Apo-1). J Exp Med 188:415-20
Bennett, S R; Carbone, F R; Toy, T et al. (1998) B cells directly tolerize CD8(+) T cells. J Exp Med 188:1977-83
Kurts, C; Carbone, F R; Barnden, M et al. (1997) CD4+ T cell help impairs CD8+ T cell deletion induced by cross-presentation of self-antigens and favors autoimmunity. J Exp Med 186:2057-62
Kurts, C; Kosaka, H; Carbone, F R et al. (1997) Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8(+) T cells. J Exp Med 186:239-45
Kim, S K; Reed, D S; Heath, W R et al. (1997) Activation and migration of CD8 T cells in the intestinal mucosa. J Immunol 159:4295-306

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