In the absence of curative medical therapy or vaccines to prevent Human Immunodeficiency Virus (HIV) infections, behavioral change, including condom use has been promoted for reducing the risk of sexually transmitted HIV acquisition. Although the potential benefits of condom use appear self-evident, many individuals at risk for HIV fail to use them. Recent considerations have resulted in appreciation of a number of additional shortfalls in current understanding of condom use. The objective of this project is to examine the use of condoms to prevent acquisition of STDs including HIV in both a high-risk and a community- based population in Baltimore.
The specific aims of the proposed study are: 1. To describe the prevalence of condom use and the characteristics of condom users, as compared to those who do not use condoms in studies of high risk patients ages 14-35 attending Baltimore STD clinics and in a community-based sample of Baltimore residents ages 14-35 years; 2. To develop more accurate measures of self-reported condom use behavior, validating these measures by detection of incident STDs; 3. To analyze determinants of condom use to prevent STDs in STD clinic patients and in city residents, and of changes in condom use over time in the clinic population; 4. To compare condom use in STD clinic patients infected with an STD closely linked to HIV risk (syphilis) to condom use in patients with other STDs. The conceptual framework and hypotheses for this project are based on a modified Health Belief Model adapted to the problem of condom use. The STD clinic study design will utilize rolling enrollment of 2,250 clients over three years, evaluated with baseline interviews and a followed-up at 6 months to monitor behavior change and to validate self-reported condom use by detection of incident infections. The community-based surveys will be conducted in two waves, two years, apart using an instrument incorporating the same questions as the STD clinic study, using telephone and face-to-face interviews in a 3:1 ratio. The project will result in two data sets which will be analyzed separately and in integrated fashion. this project will contribute needed knowledge on condom use which will be important for design of interventions for condom use to prevent HIV infections in both high-risk and general populations.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
1R01AI029508-01
Application #
3144366
Study Section
(SRC)
Project Start
1989-09-01
Project End
1994-07-31
Budget Start
1989-09-01
Budget End
1990-07-31
Support Year
1
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Jadack, R A; Fresia, A; Rompalo, A M et al. (1997) Reasons for not using condoms of clients at urban sexually transmitted diseases clinics. Sex Transm Dis 24:402-8
Peek, M; Zenilman, J M (1997) Sexually transmitted diseases in patients attending a Baltimore tuberculosis clinic. Assessment of use of multiple categoric services. Sex Transm Dis 24:8-10
Ellish, N J; Weisman, C S; Celentano, D et al. (1996) Reliability of partner reports of sexual history in a heterosexual population at a sexually transmitted diseases clinic. Sex Transm Dis 23:446-52
Golden, M R; Rompalo, A M; Fantry, L et al. (1996) Early intervention for human immunodeficiency virus in Baltimore Sexually Transmitted Diseases Clinics. Impact on gonorrhea incidence in patients infected with HIV. Sex Transm Dis 23:370-7
Quinn, T C; Gaydos, C; Shepherd, M et al. (1996) Epidemiologic and microbiologic correlates of Chlamydia trachomatis infection in sexual partnerships. JAMA 276:1737-42
Zenilman, J M; Weisman, C S; Rompalo, A M et al. (1995) Condom use to prevent incident STDs: the validity of self-reported condom use. Sex Transm Dis 22:15-21
Thomas, D L; Zenilman, J M; Alter, H J et al. (1995) Sexual transmission of hepatitis C virus among patients attending sexually transmitted diseases clinics in Baltimore--an analysis of 309 sex partnerships. J Infect Dis 171:768-75
Thomas, D L; Rompalo, A M; Zenilman, J et al. (1994) Association of hepatitis C virus infection with false-positive tests for syphilis. J Infect Dis 170:1579-81
Zenilman, J M; Hook 3rd, E W; Shepherd, M et al. (1994) Alcohol and other substance use in STD clinic patients: relationships with STDs and prevalent HIV infection. Sex Transm Dis 21:220-5
Zenilman, J M; Erickson, B; Fox, R et al. (1992) Effect of HIV posttest counseling on STD incidence. JAMA 267:843-5

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