Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI029848-02
Application #
3144774
Study Section
Special Emphasis Panel (ARR (V3))
Project Start
1990-02-01
Project End
1991-06-30
Budget Start
1991-02-01
Budget End
1991-06-30
Support Year
2
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Brown University
Department
Type
Schools of Medicine
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912
El Kouni, Mahmoud H (2017) Pyrimidine metabolism in schistosomes: A comparison with other parasites and the search for potential chemotherapeutic targets. Comp Biochem Physiol B Biochem Mol Biol 213:55-80
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el Kouni, Mahmoud H (2007) Adenosine metabolism in Toxoplasma gondii: potential targets for chemotherapy. Curr Pharm Des 13:581-97
Yadav, Vikas; Chu, Chung K; Rais, Reem H et al. (2004) Synthesis, biological activity and molecular modeling of 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase. J Med Chem 47:1987-96
el Kouni, Mahmoud H (2003) Potential chemotherapeutic targets in the purine metabolism of parasites. Pharmacol Ther 99:283-309
Chiang, C W; Carter, N; Sullivan Jr, W J et al. (1999) The adenosine transporter of Toxoplasma gondii. Identification by insertional mutagenesis, cloning, and recombinant expression. J Biol Chem 274:35255-61
Javaid, Z Z; el Kouni, M H; Iltzsch, M H (1999) Pyrimidine nucleobase ligands of orotate phosphoribosyltransferase from Toxoplasma gondii. Biochem Pharmacol 58:1457-65
Naguib, F N; Iltzsch, M H; el Kouni, M M et al. (1995) Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyl-transferase from Toxoplasma gondii. Biochem Pharmacol 50:1685-93
Iltzsch, M H; Uber, S S; Tankersley, K O et al. (1995) Structure-activity relationship for the binding of nucleoside ligands to adenosine kinase from Toxoplasma gondii. Biochem Pharmacol 49:1501-12