Antihiv Ctl and HIV Suppressive CD8 Cells

Weinhold, Kent J.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project (R01)
• Project #: 5R01AI029852-07
• Application #: 2065254
• Study Section: AIDS and Related Research Study Section 1 (ARRA)
• Project Start: 1990-07-01
• Project End: 1999-04-30
• Budget Start: 1996-05-01
• Budget End: 1997-04-30
• Support Year: 7
• Fiscal Year: 1996

Institution

• Name: Duke University
• Department: Surgery
• Type: Schools of Medicine
• DUNS #: 071723621
• City: Durham
• State: NC
• Country: United States
• Zip Code: 27705

Publications

Demarest, J F; Jack, N; Cleghorn, F R et al. (2001) Immunologic and virologic analyses of an acutely HIV type 1-infected patient with extremely rapid disease progression. AIDS Res Hum Retroviruses 17:1333-44

Tyler, D S; Stanley, S D; Bartlett, J A et al. (1998) Lymphokine-activated killer (LAK) cell anti-HIV-1 ADCC reactivity: a potential strategy for reduction of virus-infected cellular reservoirs. J Surg Res 79:115-20

Ferrari, G; Humphrey, W; McElrath, M J et al. (1997) Clade B-based HIV-1 vaccines elicit cross-clade cytotoxic T lymphocyte reactivities in uninfected volunteers. Proc Natl Acad Sci U S A 94:1396-401

Greenberg, M L; Lacey, S F; Chen, C H et al. (1997) Noncytolytic CD8 T cell-mediated suppression of HIV replication. Springer Semin Immunopathol 18:355-69

Ferrari, G; Berend, C; Ottinger, J et al. (1997) Replication-defective canarypox (ALVAC) vectors effectively activate anti-human immunodeficiency virus-1 cytotoxic T lymphocytes present in infected patients: implications for antigen-specific immunotherapy. Blood 90:2406-16

Ferrari, G; King, K; Rathbun, K et al. (1995) IL-7 enhancement of antigen-driven activation/expansion of HIV-1-specific cytotoxic T lymphocyte precursors (CTLp). Clin Exp Immunol 101:239-48

Ahearne, P M; Morgan, R A; Sebastian, M W et al. (1995) Multiple CTL specificities against autologous HIV-1-infected BLCLs. Cell Immunol 161:34-41

Toso, J F; Chen, C H; Mohr, J R et al. (1995) Oligoclonal CD8 lymphocytes from persons with asymptomatic human immunodeficiency virus (HIV) type 1 infection inhibit HIV-1 replication. J Infect Dis 172:964-73

Ferrari, G; Place, C A; Ahearne, P M et al. (1994) Comparison of anti-HIV-1 ADCC reactivities in infected humans and chimpanzees. J Acquir Immune Defic Syndr 7:325-31

Chen, C H; Weinhold, K J; Bartlett, J A et al. (1993) CD8+ T lymphocyte-mediated inhibition of HIV-1 long terminal repeat transcription: a novel antiviral mechanism. AIDS Res Hum Retroviruses 9:1079-86