Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
2R01AI030136-07A1
Application #
2065464
Study Section
Tropical Medicine and Parasitology Study Section (TMP)
Project Start
1990-08-01
Project End
2001-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Washington State University
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
041485301
City
Pullman
State
WA
Country
United States
Zip Code
99164
Norimine, Junzo; Mosqueda, Juan; Suarez, Carlos et al. (2003) Stimulation of T-helper cell gamma interferon and immunoglobulin G responses specific for Babesia bovis rhoptry-associated protein 1 (RAP-1) or a RAP-1 protein lacking the carboxy-terminal repeat region is insufficient to provide protective immunity again Infect Immun 71:5021-32
Goff, Will L; McElwain, Terry F; Suarez, Carlos E et al. (2003) Competitive enzyme-linked immunosorbent assay based on a rhoptry-associated protein 1 epitope specifically identifies Babesia bovis-infected cattle. Clin Diagn Lab Immunol 10:38-43
Brown, Wendy C; Corral, Ricardo S (2002) Stimulation of B lymphocytes, macrophages, and dendritic cells by protozoan DNA. Microbes Infect 4:969-74
Norimine, Junzo; Suarez, Carlos E; McElwain, Terry F et al. (2002) Immunodominant epitopes in Babesia bovis rhoptry-associated protein 1 that elicit memory CD4(+)-T-lymphocyte responses in B. bovis-immune individuals are located in the amino-terminal domain. Infect Immun 70:2039-48
Shoda, L K; Kegerreis, K A; Suarez, C E et al. (2001) DNA from protozoan parasites Babesia bovis, Trypanosoma cruzi, and T. brucei is mitogenic for B lymphocytes and stimulates macrophage expression of interleukin-12, tumor necrosis factor alpha, and nitric oxide. Infect Immun 69:2162-71
Brown, W C; Ruef, B J; Norimine, J et al. (2001) A novel 20-kilodalton protein conserved in Babesia bovis and B. bigemina stimulates memory CD4(+) T lymphocyte responses in B. bovis-immune cattle. Mol Biochem Parasitol 118:97-109
Ruef, B J; Dowling, S C; Conley, P G et al. (2000) A unique Babesia bovis spherical body protein is conserved among geographic isolates and localizes to the infected erythrocyte membrane. Mol Biochem Parasitol 105:12-Jan
Shoda, L K; Palmer, G H; Florin-Christensen, J et al. (2000) Babesia bovis-stimulated macrophages express interleukin-1beta, interleukin-12, tumor necrosis factor alpha, and nitric oxide and inhibit parasite replication in vitro. Infect Immun 68:5139-45
Ruef, B J; Ward, T J; Oxner, C R et al. (2000) Phylogenetic analysis with newly characterized Babesia bovis hsp70 and hsp90 provides strong support for paraphyly within the piroplasms. Mol Biochem Parasitol 109:67-72
Tuo, W; Palmer, G H; McGuire, T C et al. (2000) Interleukin-12 as an adjuvant promotes immunoglobulin G and type 1 cytokine recall responses to major surface protein 2 of the ehrlichial pathogen Anaplasma marginale. Infect Immun 68:270-80

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