Genital herpes continues to be epidemic throughout most sexually active populations in the United States. Despite many advances in our knowledge of the disease, particularly with respect to therapeutic modalities, little is known about the natural history of symptomatic genital HSV infection. This application is directed at performing statistical analyses on the natural history and long term clinical course of genital herpes infection. the offerers have established a database encompassing over 15 years of clinical and laboratory information on individuals with symptomatic genital infection who were prospectively followed over time. We propose to utilize this database in order to evaluate the relationships of viral type, initial disease severity, immune response and demographic characteristics to subsequent recurrences of the disease. This proposal expands the scope of our previous studies, which were limited to select subsets of this database. The magnitude of this database will allow us to extend our previous observations using more complex statistical models, and to test new hypothesis arising from our evolving understanding of the relationship between host and epidemiologic factors and disease course.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI030619-02
Application #
2065773
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1992-04-01
Project End
1996-03-31
Budget Start
1993-04-01
Budget End
1996-03-31
Support Year
2
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Washington
Department
Biostatistics & Other Math Sci
Type
Schools of Public Health
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Benedetti, J K; Zeh, J; Corey, L (1999) Clinical reactivation of genital herpes simplex virus infection decreases in frequency over time. Ann Intern Med 131:14-20
Benedetti, J K; Zeh, J; Selke, S et al. (1995) Frequency and reactivation of nongenital lesions among patients with genital herpes simplex virus. Am J Med 98:237-42
Benedetti, J; Corey, L; Ashley, R (1994) Recurrence rates in genital herpes after symptomatic first-episode infection. Ann Intern Med 121:847-54