Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI030726-06
Application #
2065844
Study Section
Molecular and Cellular Biophysics Study Section (BBCA)
Project Start
1990-12-01
Project End
1998-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Colorado at Boulder
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
City
Boulder
State
CO
Country
United States
Zip Code
80309
Boots, Jennifer L; Canny, Marella D; Azimi, Ehsan et al. (2008) Metal ion specificities for folding and cleavage activity in the Schistosoma hammerhead ribozyme. RNA 14:2212-22
Canny, Marella D; Jucker, Fiona M; Pardi, Arthur (2007) Efficient ligation of the Schistosoma hammerhead ribozyme. Biochemistry 46:3826-34
Lee, Joon-Hwa; Pardi, Arthur (2007) Thermodynamics and kinetics for base-pair opening in the P1 duplex of the Tetrahymena group I ribozyme. Nucleic Acids Res 35:2965-74
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Canny, Marella D; Jucker, Fiona M; Kellogg, Elizabeth et al. (2004) Fast cleavage kinetics of a natural hammerhead ribozyme. J Am Chem Soc 126:10848-9
Jucker, Fiona M; Phillips, Rebecca M; McCallum, Scott A et al. (2003) Role of a heterogeneous free state in the formation of a specific RNA-theophylline complex. Biochemistry 42:2560-7
Bondensgaard, Kent; Mollova, Emilia T; Pardi, Arthur (2002) The global conformation of the hammerhead ribozyme determined using residual dipolar couplings. Biochemistry 41:11532-42
Sibille, N; Pardi, A; Simorre, J P et al. (2001) Refinement of local and long-range structural order in theophylline-binding RNA using (13)C-(1)H residual dipolar couplings and restrained molecular dynamics. J Am Chem Soc 123:12135-46
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Hansen, M R; Simorre, J P; Hanson, P et al. (1999) Identification and characterization of a novel high affinity metal-binding site in the hammerhead ribozyme. RNA 5:1099-104

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