Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
2R01AI031337-06A1
Application #
2066293
Study Section
AIDS and Related Research Study Section 1 (ARRA)
Project Start
1991-03-01
Project End
1997-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02215
Vidard, L; Kovacsovics-Bankowski, M; Kraeft, S K et al. (1996) Analysis of MHC class II presentation of particulate antigens of B lymphocytes. J Immunol 156:2809-18
Falo Jr, L D; Kovacsovics-Bankowski, M; Thompson, K et al. (1995) Targeting antigen into the phagocytic pathway in vivo induces protective tumour immunity. Nat Med 1:649-53
Kovacsovics-Bankowski, M; Rock, K L (1995) A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules. Science 267:243-6
Kovacsovics-Bankowski, M; Rock, K L (1994) Presentation of exogenous antigens by macrophages: analysis of major histocompatibility complex class I and II presentation and regulation by cytokines. Eur J Immunol 24:2421-8
Rock, K L; Fleischacker, C; Gamble, S (1993) Peptide-priming of cytolytic T cell immunity in vivo using beta 2-microglobulin as an adjuvant. J Immunol 150:1244-52
Rock, K L; Rothstein, L; Gamble, S et al. (1993) Characterization of antigen-presenting cells that present exogenous antigens in association with class I MHC molecules. J Immunol 150:438-46
Kovacsovics-Bankowski, M; Clark, K; Benacerraf, B et al. (1993) Efficient major histocompatibility complex class I presentation of exogenous antigen upon phagocytosis by macrophages. Proc Natl Acad Sci U S A 90:4942-6
Falo Jr, L D; Colarusso, L J; Benacerraf, B et al. (1992) Serum proteases alter the antigenicity of peptides presented by class I major histocompatibility complex molecules. Proc Natl Acad Sci U S A 89:8347-50
Grant, E P; Rock, K L (1992) MHC class I-restricted presentation of exogenous antigen by thymic antigen-presenting cells in vitro and in vivo. J Immunol 148:13-8