Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI031418-05
Application #
2066360
Study Section
Immunological Sciences Study Section (IMS)
Project Start
1992-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Boston University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Liu, Jiajian; Beller, David (2002) Aberrant production of IL-12 by macrophages from several autoimmune-prone mouse strains is characterized by intrinsic and unique patterns of NF-kappa B expression and binding to the IL-12 p40 promoter. J Immunol 169:581-6
Alleva, D G; Pavlovich, R P; Grant, C et al. (2000) Aberrant macrophage cytokine production is a conserved feature among autoimmune-prone mouse strains: elevated interleukin (IL)-12 and an imbalance in tumor necrosis factor-alpha and IL-10 define a unique cytokine profile in macrophages from young nonobese Diabetes 49:1106-15
Alleva, D G; Kaser, S B; Beller, D I (1998) Intrinsic defects in macrophage IL-12 production associated with immune dysfunction in the MRL/++ and New Zealand Black/White F1 lupus-prone mice and the Leishmania major-susceptible BALB/c strain. J Immunol 161:6878-84
Levine, J S; Koh, J S; Hartwell, D et al. (1998) Adhesion elicits an intrinsic defect in interleukin-1 expression by macrophages from autoimmune-prone MRL mice. J Autoimmun 11:141-50
Kung, J T; Beller, D; Ju, S T (1998) Lymphokine regulation of activation-induced apoptosis in T cells of IL-2 and IL-2R beta knockout mice. Cell Immunol 185:158-63
Alleva, D G; Kaser, S B; Monroy, M A et al. (1997) IL-15 functions as a potent autocrine regulator of macrophage proinflammatory cytokine production: evidence for differential receptor subunit utilization associated with stimulation or inhibition. J Immunol 159:2941-51
Alleva, D G; Kaser, S B; Beller, D I (1997) Aberrant cytokine expression and autocrine regulation characterize macrophages from young MRL+/+ and NZB/W F1 lupus-prone mice. J Immunol 159:5610-9
Fitzpatrick, J M; Koh, J S; Hartwell, D et al. (1996) Dysregulated cytokine expression in vivo in prediseased and diseased autoimmune-prone MRL mice. Autoimmunity 23:217-29
Hartwell, D W; Fenton, M J; Levine, J S et al. (1995) Aberrant cytokine regulation in macrophages from young autoimmune-prone mice: evidence that the intrinsic defect in MRL macrophage IL-1 expression is transcriptionally controlled. Mol Immunol 32:743-51
Hartwell, D; Levine, J; Fenton, M et al. (1994) Cytokine dysregulation and the initiation of systemic autoimmunity. Immunol Lett 43:15-21

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