The goal of this study is to improve understanding and management of postinfectious chronic fatigue. The first specific aim is to determine whether post Lyme syndrome (PLS) is antibiotic-responsive. The second is to determine whether cerebrospinal fluid (CSF) markers in these patients predict treatment response.
The third aim i s to determine whether premorbid psychosocial factors predict poor treatment outcome. Post treatment Lyme syndrome patients (N=50) will be evaluated at entry for fatigue, CSF and cognitive disturbances. Patients will be randomized to receive four weeks of intravenous ceftriaxone or placebo treatment. Patients will be re-evaluated at one month post treatment for fatigue response, and at six months post treatment for fatigue, CSF and cognitive response.
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