Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
2R01AI031613-05A1
Application #
2066607
Study Section
Immunobiology Study Section (IMB)
Project Start
1992-05-01
Project End
2001-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Salk Institute for Biological Studies
Department
Type
DUNS #
005436803
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Lesley, Jayne; Gal, Istvan; Mahoney, David J et al. (2004) TSG-6 modulates the interaction between hyaluronan and cell surface CD44. J Biol Chem 279:25745-54
Gal, Istvan; Lesley, Jayne; Ko, Wendy et al. (2003) Role of the extracellular and cytoplasmic domains of CD44 in the rolling interaction of lymphoid cells with hyaluronan under physiologic flow. J Biol Chem 278:11150-8
Lesley, Jayne; English, Nicole M; Gal, Istvan et al. (2002) Hyaluronan binding properties of a CD44 chimera containing the link module of TSG-6. J Biol Chem 277:26600-8
Hyman, Robert (2002) Lack of a consistent relationship between demethylation of the CD44 promoter and CD44 expression. Immunogenetics 53:914-24
Lesley, J; Hascall, V C; Tammi, M et al. (2000) Hyaluronan binding by cell surface CD44. J Biol Chem 275:26967-75
Kim, J H; Glant, T T; Lesley, J et al. (2000) Adhesion of lymphoid cells to CD44-specific substrata: the consequences of attachment depend on the ligand. Exp Cell Res 256:445-53
Lesley, J; English, N; Charles, C et al. (2000) The role of the CD44 cytoplasmic and transmembrane domains in constitutive and inducible hyaluronan binding. Eur J Immunol 30:245-53
English, N M; Lesley, J F; Hyman, R (1998) Site-specific de-N-glycosylation of CD44 can activate hyaluronan binding, and CD44 activation states show distinct threshold densities for hyaluronan binding. Cancer Res 58:3736-42
Perschl, A; Lesley, J; English, N et al. (1995) Role of CD44 cytoplasmic domain in hyaluronan binding. Eur J Immunol 25:495-501
Perschl, A; Lesley, J; English, N et al. (1995) Transmembrane domain of CD44 is required for its detergent insolubility in fibroblasts. J Cell Sci 108 ( Pt 3):1033-41

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