Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI031963-05
Application #
2066889
Study Section
Allergy and Immunology Study Section (ALY)
Project Start
1991-12-01
Project End
1996-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Carney, D F; Jagels, M A; Hugli, T E et al. (1998) Effect of serine proteinase inhibitors on neutrophil function: alpha-1-proteinase inhibitor, antichymotrypsin, and a recombinant hybrid mutant of antichymotrypsin (LEX032) modulate neutrophil adhesion interactions. J Leukoc Biol 63:75-82
Ni, F; Carpenter, K A; Ripoll, D R et al. (1996) Stabilization of an isolated helical capping box in solution by hydrophobic interactions: evidence from the NMR study of bioactive peptides from the C-terminus of human C5a anaphylatoxin. Biopolymers 38:31-41
Discipio, R G; Daffern, P J; Kawahara, M et al. (1996) Cleavage of human complement component C5 by cysteine proteinases from Porphyromonas (Bacteroides) gingivalis. Prior oxidation of C5 augments proteinase digestion of C5. Immunology 87:660-7
Daffern, P J; Pfeifer, P H; Ember, J A et al. (1995) C3a is a chemotaxin for human eosinophils but not for neutrophils. I. C3a stimulation of neutrophils is secondary to eosinophil activation. J Exp Med 181:2119-27
Jagels, M A; Chambers, J D; Arfors, K E et al. (1995) C5a- and tumor necrosis factor-alpha-induced leukocytosis occurs independently of beta 2 integrins and L-selectin: differential effects on neutrophil adhesion molecule expression in vivo. Blood 85:2900-9
Jagels, M A; Hugli, T E (1994) Mechanisms and mediators of neutrophilic leukocytosis. Immunopharmacology 28:1-18
Hetland, G; del Zoppo, G J; Mori, E et al. (1994) Uptake of C5a by polymorphonuclear leukocytes (PMNs) after focal cerebral ischemia. I. Effect of tirilazad mesylate intervention on C5a uptake by PMNs. Immunopharmacology 27:191-8
Cui, L; Carney, D F; Hugli, T E (1994) Primary structure and functional characterization of rat C5a: an anaphylatoxin with unusually high potency. Protein Sci 3:1169-77
Ember, J A; del Zoppo, G J; Mori, E et al. (1994) Polymorphonuclear leukocyte behavior in a nonhuman primate focal ischemia model. J Cereb Blood Flow Metab 14:1046-54
Tsai, W M; Roos, G; Hugli, T E et al. (1992) Influence of free thiol group(s) on autoantibody-defined epitope of proliferating cell nuclear antigen. J Immunol 149:2227-33

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