Early Events in Thymic Positive Selection

Kaye, Jonathan G.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project (R01)
• Project #: 2R01AI033219-04
• Application #: 2068215
• Study Section: Experimental Immunology Study Section (EI)
• Project Start: 1993-05-01
• Project End: 2000-04-30
• Budget Start: 1996-05-01
• Budget End: 1997-04-30
• Support Year: 4
• Fiscal Year: 1996

Institution

• Name: Scripps Research Institute
• City: La Jolla
• State: CA
• Country: United States
• Zip Code: 92037

Publications

Shao, H; Wilkinson, B; Lee, B et al. (1999) Slow accumulation of active mitogen-activated protein kinase during thymocyte differentiation regulates the temporal pattern of transcription factor gene expression. J Immunol 163:603-10

Dekoning, J; Kaye, J G (1997) Requirements for differentiation of an immature CD4+8+ T-cell line. Dev Immunol 5:91-103

Shao, H; Kono, D H; Chen, L Y et al. (1997) Induction of the early growth response (Egr) family of transcription factors during thymic selection. J Exp Med 185:731-44

DeKoning, J; Carbone, F R; Kaye, J (1995) Contrast between class I and class II MHC-mediated differentiation of a CD4+CD8+ T cell line: implications for lineage commitment. Int Immunol 7:541-9

Poirier, G; Lo, D; Reilly, C R et al. (1994) Discrimination between thymic epithelial cells and peripheral antigen-presenting cells in the induction of immature T cell differentiation. Immunity 1:385-91