Lps-Induced Signaling in Macrophages

Defranco, Anthony L.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project (R01)
• Project #: 2R01AI033442-04
• Application #: 2068446
• Study Section: Bacteriology and Mycology Subcommittee 2 (BM)
• Project Start: 1993-08-01
• Project End: 2000-07-31
• Budget Start: 1996-08-01
• Budget End: 1997-07-31
• Support Year: 4
• Fiscal Year: 1996

Institution

• Name: University of California San Francisco
• Department: Microbiology/Immun/Virology
• Type: Schools of Medicine
• DUNS #: 073133571
• City: San Francisco
• State: CA
• Country: United States
• Zip Code: 94143

Publications

Nishiya, Tadashi; Kajita, Emi; Miwa, Soichi et al. (2005) TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements. J Biol Chem 280:37107-17

Nishiya, Tadashi; DeFranco, Anthony L (2004) Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors. J Biol Chem 279:19008-17

Weinstein, S L; Finn, A J; Dave, S H et al. (2000) Phosphatidylinositol 3-kinase and mTOR mediate lipopolysaccharide-stimulated nitric oxide production in macrophages via interferon-beta. J Leukoc Biol 67:405-14

MacKichan, M L; DeFranco, A L (1999) Role of ceramide in lipopolysaccharide (LPS)-induced signaling. LPS increases ceramide rather than acting as a structural homolog. J Biol Chem 274:1767-75

Crowley, M T; Costello, P S; Fitzer-Attas, C J et al. (1997) A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages. J Exp Med 186:1027-39

Crowley, M T; Harmer, S L; DeFranco, A L (1996) Activation-induced association of a 145-kDa tyrosine-phosphorylated protein with Shc and Syk in B lymphocytes and macrophages. J Biol Chem 271:1145-52