Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
3R01AI033702-03S1
Application #
2068758
Study Section
Special Emphasis Panel (SRC (59))
Project Start
1992-09-30
Project End
1996-08-31
Budget Start
1994-09-01
Budget End
1995-08-31
Support Year
3
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Chambers, Henry F; Turner, Joan; Schecter, Gisela F et al. (2005) Imipenem for treatment of tuberculosis in mice and humans. Antimicrob Agents Chemother 49:2816-21
Liu, J; Nikaido, H (1999) A mutant of Mycobacterium smegmatis defective in the biosynthesis of mycolic acids accumulates meromycolates. Proc Natl Acad Sci U S A 96:4011-6
Chambers, H F; Kocagoz, T; Sipit, T et al. (1998) Activity of amoxicillin/clavulanate in patients with tuberculosis. Clin Infect Dis 26:874-7
Hackbarth, C J; Unsal, I; Chambers, H F (1997) Cloning and sequence analysis of a class A beta-lactamase from Mycobacterium tuberculosis H37Ra. Antimicrob Agents Chemother 41:1182-5
Liu, J; Barry 3rd, C E; Besra, G S et al. (1996) Mycolic acid structure determines the fluidity of the mycobacterial cell wall. J Biol Chem 271:29545-51
Kocagoz, T; Hackbarth, C J; Unsal, I et al. (1996) Gyrase mutations in laboratory-selected, fluoroquinolone-resistant mutants of Mycobacterium tuberculosis H37Ra. Antimicrob Agents Chemother 40:1768-74
Liu, J; Takiff, H E; Nikaido, H (1996) Active efflux of fluoroquinolones in Mycobacterium smegmatis mediated by LfrA, a multidrug efflux pump. J Bacteriol 178:3791-5
Sweet-Cordero, E A; Chambers, H F; Cicero-Sabido, R et al. (1996) Burden of Mycobacterium tuberculosis in sputum samples can be reliably determined using a quantitative, non-radioactive polymerase chain reaction assay. Tuber Lung Dis 77:496-501
Hackbarth, C J; Kocagoz, T; Kocagoz, S et al. (1995) Point mutations in Staphylococcus aureus PBP 2 gene affect penicillin-binding kinetics and are associated with resistance. Antimicrob Agents Chemother 39:103-6
Chambers, H F (1995) In vitro and in vivo antistaphylococcal activities of L-695,256, a carbapenem with high affinity for the penicillin-binding protein PBP 2a. Antimicrob Agents Chemother 39:462-6

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