Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI034133-03
Application #
2069214
Study Section
AIDS and Related Research Study Section 4 (ARRD)
Project Start
1993-01-01
Project End
1996-12-31
Budget Start
1995-01-01
Budget End
1996-12-31
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of Utah
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112

  Publications

Johnson, Mark D; Chen, Jian; Anderson, Bradley D (2002) Investigation of the mechanism of enhancement of central nervous system delivery of 2'-beta-fluoro-2',3'-dideoxyinosine via a blood-brain barrier adenosine deaminase-activated prodrug. Drug Metab Dispos 30:191-8
Johnson, M D; Anderson, B D (2000) Use of cultured cerebral capillary endothelial cells in modeling the central nervous system availability of 2',3'-dideoxyinosine. J Pharm Sci 89:322-35
Johnson, M D; Anderson, B D (1999) In vitro models of the blood-brain barrier to polar permeants: comparison of transmonolayer flux measurements and cell uptake kinetics using cultured cerebral capillary endothelial cells. J Pharm Sci 88:620-5
Singhal, D; Ho, N F; Anderson, B D (1998) Absorption and intestinal metabolism of purine dideoxynucleosides and an adenosine deaminase-activated prodrug of 2',3'-dideoxyinosine in the mesenteric vein cannulated rat ileum. J Pharm Sci 87:569-77
Singhal, D; Anderson, B D (1998) Optimization of the local inhibition of intestinal adenosine deaminase (ADA) by erythro-9-(2-hydroxy-3-nonyl)adenine: enhanced oral delivery of an ADA-activated prodrug for anti-HIV therapy. J Pharm Sci 87:578-85
Singhal, D; Morgan, M E; Anderson, B D (1997) Role of brain tissue localized purine metabolizing enzymes in the central nervous system delivery of anti-HIV agents 2'-beta-fluoro-2',3'-dideoxyinosine and 2'-beta-fluoro-2',3'-dideoxyadenosine in rats. Pharm Res 14:786-92
Singhal, D; Morgan, M E; Anderson, B D (1996) Role of altered metabolism in dideoxynucleoside pharmacokinetics. Studies of 2'-beta-fluoro-2',3'-dideoxyinosine and 2'-beta-fluoro-2',3'-dideoxyadenosine in rats. Drug Metab Dispos 24:1155-61
Johnson, M D; Anderson, B D (1996) Localization of purine metabolizing enzymes in bovine brain microvessel endothelial cells: an enzymatic blood-brain barrier for dideoxynucleosides? Pharm Res 13:1881-6
Morgan, M E; Singhal, D; Anderson, B D (1996) Quantitative assessment of blood-brain barrier damage during microdialysis. J Pharmacol Exp Ther 277:1167-76
Anderson, B D; Morgan, M E; Singhal, D (1995) Enhanced oral bioavailability of DDI after administration of 6-Cl-ddP, an adenosine deaminase-activated prodrug, to chronically catheterized rats. Pharm Res 12:1126-33