D-Ala-D-Ala Ligase and Bacterial Vancomycin Resistance

Knox, James Russell

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project (R01)
• Project #: 5R01AI034330-03
• Application #: 2069447
• Study Section: Biophysical Chemistry Study Section (BBCB)
• Project Start: 1993-09-01
• Project End: 1996-08-31
• Budget Start: 1995-09-01
• Budget End: 1996-08-31
• Support Year: 3
• Fiscal Year: 1995

Institution

• Name: University of Connecticut
• Department: Biochemistry
• Type: Schools of Arts and Sciences
• City: Storrs-Mansfield
• State: CT
• Country: United States
• Zip Code: 06269

Publications

Healy, V L; Lessard, I A; Roper, D I et al. (2000) Vancomycin resistance in enterococci: reprogramming of the D-ala-D-Ala ligases in bacterial peptidoglycan biosynthesis. Chem Biol 7:R109-19

Fan, C; Park, I S; Walsh, C T et al. (1997) D-alanine:D-alanine ligase: phosphonate and phosphinate intermediates with wild type and the Y216F mutant. Biochemistry 36:2531-8

Fan, C; Moews, P C; Shi, Y et al. (1995) A common fold for peptide synthetases cleaving ATP to ADP: glutathione synthetase and D-alanine:d-alanine ligase of Escherichia coli. Proc Natl Acad Sci U S A 92:1172-6

Fan, C; Moews, P C; Walsh, C T et al. (1994) Vancomycin resistance: structure of D-alanine:D-alanine ligase at 2.3 A resolution. Science 266:439-43