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Schramm, Vern L (2005) Enzymatic transition states: thermodynamics, dynamics and analogue design. Arch Biochem Biophys 433:13-26
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Parikh, Sapan L; Schramm, Vern L (2004) Transition state structure for ADP-ribosylation of eukaryotic elongation factor 2 catalyzed by diphtheria toxin. Biochemistry 43:1204-12
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Zhou, Guo-Chun; Parikh, Sapan L; Tyler, Peter C et al. (2004) Inhibitors of ADP-ribosylating bacterial toxins based on oxacarbenium ion character at their transition states. J Am Chem Soc 126:5690-8
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Sauve, Anthony A; Schramm, Vern L (2003) Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry. Biochemistry 42:9249-56
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Sauve, Anthony A; Schramm, Vern L (2002) Mechanism-based inhibitors of CD38: a mammalian cyclic ADP-ribose synthetase. Biochemistry 41:8455-63
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Sauve, A A; Celic, I; Avalos, J et al. (2001) Chemistry of gene silencing: the mechanism of NAD+-dependent deacetylation reactions. Biochemistry 40:15456-63
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Berti, P J (1999) Determining transition states from kinetic isotope effects. Methods Enzymol 308:355-97
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Braunheim, B B; Miles, R W; Schramm, V L et al. (1999) Prediction of inhibitor binding free energies by quantum neural networks. Nucleoside analogues binding to trypanosomal nucleoside hydrolase. Biochemistry 38:16076-83
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Sauve, A A; Munshi, C; Lee, H C et al. (1998) The reaction mechanism for CD38. A single intermediate is responsible for cyclization, hydrolysis, and base-exchange chemistries. Biochemistry 37:13239-49
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Scheuring, J; Berti, P J; Schramm, V L (1998) Transition-state structure for the ADP-ribosylation of recombinant Gialpha1 subunits by pertussis toxin. Biochemistry 37:2748-58
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