Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI034359-03
Application #
2069487
Study Section
Immunobiology Study Section (IMB)
Project Start
1994-05-01
Project End
1998-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Chicago
Department
Pathology
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637

  Publications

Lazarski, Christopher A; Chaves, Francisco A; Jenks, Scott A et al. (2005) The kinetic stability of MHC class II:peptide complexes is a key parameter that dictates immunodominance. Immunity 23:29-40
McFarland, Benjamin J; Katz, John F; Sant, Andrea J et al. (2005) Energetics and cooperativity of the hydrogen bonding and anchor interactions that bind peptides to MHC class II protein. J Mol Biol 350:170-83
Chaves, Francisco A; Hou, Ping; Wu, Shenhong et al. (2005) Replacement of the membrane proximal region of I-A(d) MHC class II molecule with I-E-derived sequences promotes production of an active and stable soluble heterodimer without altering peptide-binding specificity. J Immunol Methods 300:74-92
McFarland, B J; Katz, J F; Beeson, C et al. (2001) Energetic asymmetry among hydrogen bonds in MHC class II*peptide complexes. Proc Natl Acad Sci U S A 98:9231-6
Arneson, L S; Katz, J F; Liu, M et al. (2001) Hydrogen bond integrity between MHC class II molecules and bound peptide determines the intracellular fate of MHC class II molecules. J Immunol 167:6939-46
Arneson, L S; Peterson, M; Sant, A J (2000) The MHC class II molecule I-Ag7 exists in alternate conformations that are peptide dependent. J Immunol 165:2059-67
McFarland, B J; Beeson, C; Sant, A J (1999) Cutting edge: a single, essential hydrogen bond controls the stability of peptide-MHC class II complexes. J Immunol 163:3567-71
McFarland, B J; Sant, A J; Lybrand, T P et al. (1999) Ovalbumin(323-339) peptide binds to the major histocompatibility complex class II I-A(d) protein using two functionally distinct registers. Biochemistry 38:16663-70
Ceman, S; Wu, S; Jardetzky, T S et al. (1998) Alteration of a single hydrogen bond between class II molecules and peptide results in rapid degradation of class II molecules after invariant chain removal. J Exp Med 188:2139-49
Peterson, M; Sant, A J (1998) The inability of the nonobese diabetic class II molecule to form stable peptide complexes does not reflect a failure to interact productively with DM. J Immunol 161:2961-7

Showing the most recent 10 out of 13 publications