Structure-Function Studies of Sivsm Vpx and Vpr

Hahn, Beatrice H.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project (R01)
• Project #: 5R01AI034748-03
• Application #: 2069900
• Study Section: AIDS and Related Research Study Section 1 (ARRA)
• Project Start: 1994-01-01
• Project End: 1996-12-31
• Budget Start: 1996-01-01
• Budget End: 1996-12-31
• Support Year: 3
• Fiscal Year: 1996

Institution

• Name: University of Alabama Birmingham
• Department: Internal Medicine/Medicine
• Type: Schools of Medicine
• DUNS #: 004514360
• City: Birmingham
• State: AL
• Country: United States
• Zip Code: 35294

Publications

Mahalingam, S; Van Tine, B; Santiago, M L et al. (2001) Functional analysis of the simian immunodeficiency virus Vpx protein: identification of packaging determinants and a novel nuclear targeting domain. J Virol 75:362-74

Goh, W C; Rogel, M E; Kinsey, C M et al. (1998) HIV-1 Vpr increases viral expression by manipulation of the cell cycle: a mechanism for selection of Vpr in vivo. Nat Med 4:65-71

Stivahtis, G L; Soares, M A; Vodicka, M A et al. (1997) Conservation and host specificity of Vpr-mediated cell cycle arrest suggest a fundamental role in primate lentivirus evolution and biology. J Virol 71:4331-8

Fletcher 3rd, T M; Soares, M A; McPhearson, S et al. (1997) Complementation of integrase function in HIV-1 virions. EMBO J 16:5123-38

Fletcher 3rd, T M; Brichacek, B; Sharova, N et al. (1996) Nuclear import and cell cycle arrest functions of the HIV-1 Vpr protein are encoded by two separate genes in HIV-2/SIV(SM). EMBO J 15:6155-65