HIV-1 Inhibition by 2-5 Derivatives, 2-50as & Pkr Genes

Suhadolnik, Robert J.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project (R01)
• Project #: 5R01AI034765-02
• Application #: 2069931
• Study Section: AIDS and Related Research Study Section 4 (ARRD)
• Project Start: 1995-08-01
• Project End: 1998-07-31
• Budget Start: 1996-08-01
• Budget End: 1997-07-31
• Support Year: 2
• Fiscal Year: 1996

Institution

• Name: Temple University
• Department: Biochemistry
• Type: Schools of Medicine
• City: Philadelphia
• State: PA
• Country: United States
• Zip Code: 19122

Publications

Dimitrova, Dessislava I; Reichenbach, Nancy L; Yang, Xiaowei et al. (2007) Inhibition of HIV type 1 replication in CD4+ and CD14+ cells purified from HIV type 1-infected individuals by the 2-5A agonist immunomodulator, 2-5A(N6B). AIDS Res Hum Retroviruses 23:123-34

Dimitrova, Dessislava I; Yang, Xiaowei; Reichenbach, Nancy L et al. (2005) Lentivirus-mediated transduction of PKR into CD34(+) hematopoietic stem cells inhibits HIV-1 replication in differentiated T cell progeny. J Interferon Cytokine Res 25:345-60

Homan, Joseph W; Steele, Amber D; Martinand-Mari, Camille et al. (2002) Inhibition of morphine-potentiated HIV-1 replication in peripheral blood mononuclear cells with the nuclease-resistant 2-5A agonist analog, 2-5A(N6B). J Acquir Immune Defic Syndr 30:9-20

Adelson, M E; Martinand-Mari, C; Iacono, K T et al. (1999) Inhibition of human immunodeficiency virus (HIV-1) replication in SupT1 cells transduced with an HIV-1 LTR-driven PKR cDNA construct. Eur J Biochem 264:806-15

Muto, N F; Martinand-Mari, C; Adelson, M E et al. (1999) Inhibition of replication of reactivated human immunodeficiency virus type 1 (HIV-1) in latently infected U1 cells transduced with an HIV-1 long terminal repeat-driven PKR cDNA construct. J Virol 73:9021-8

Kon, N; Suhadolnik, R J (1996) Identification of the ATP binding domain of recombinant human 40-kDa 2',5'-oligoadenylate synthetase by photoaffinity labeling with 8-azido-[alpha-32P]ATP. J Biol Chem 271:19983-90