Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI034946-03
Application #
2070238
Study Section
Virology Study Section (VR)
Project Start
1994-01-01
Project End
1997-06-30
Budget Start
1996-01-01
Budget End
1997-06-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Massachusetts Medical School Worcester
Department
Pathology
Type
Schools of Medicine
DUNS #
660735098
City
Worcester
State
MA
Country
United States
Zip Code
01655
Oran, Alp E; Robinson, Harriet L (2004) DNA vaccines: influenza virus challenge of a Th2/Tc2 immune response results in a Th2/Tc1 response in the lung. J Virol 78:4376-80
Bright, Rick A; Ross, Ted M; Subbarao, Kanta et al. (2003) Impact of glycosylation on the immunogenicity of a DNA-based influenza H5 HA vaccine. Virology 308:270-8
Oran, Alp E; Robinson, Harriet L (2003) DNA vaccines, combining form of antigen and method of delivery to raise a spectrum of IFN-gamma and IL-4-producing CD4+ and CD8+ T cells. J Immunol 171:1999-2005
Sasaki, S; Xin, K-Q; Okudela, K et al. (2002) Immunomodulation by apoptosis-inducing caspases for an influenza DNA vaccine delivered by gene gun. Gene Ther 9:828-31
Sasaki, Shin; Amara, Rama Rao; Yeow, Wen-Shuz et al. (2002) Regulation of DNA-raised immune responses by cotransfected interferon regulatory factors. J Virol 76:6652-9
Sasaki, S; Amara, R R; Oran, A E et al. (2001) Apoptosis-mediated enhancement of DNA-raised immune responses by mutant caspases. Nat Biotechnol 19:543-7
Pertmer, T M; Oran, A E; Madorin, C A et al. (2001) Th1 genetic adjuvants modulate immune responses in neonates. Vaccine 19:1764-71
Pertmer, T M; Oran, A E; Moser, J M et al. (2000) DNA vaccines for influenza virus: differential effects of maternal antibody on immune responses to hemagglutinin and nucleoprotein. J Virol 74:7787-93
Boyle, C M; Robinson, H L (2000) Basic mechanisms of DNA-raised antibody responses to intramuscular and gene gun immunizations. DNA Cell Biol 19:157-65
Ross, T M; Xu, Y; Bright, R A et al. (2000) C3d enhancement of antibodies to hemagglutinin accelerates protection against influenza virus challenge. Nat Immunol 1:127-31

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