Tnf Signaling - Activation of Nf-Kb and Gene Expression

Baldwin, Albert Sidney

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project (R01)
• Project #: 5R01AI035098-03
• Application #: 2070492
• Study Section: Allergy and Immunology Study Section (ALY)
• Project Start: 1994-01-01
• Project End: 1998-12-31
• Budget Start: 1996-01-01
• Budget End: 1996-12-31
• Support Year: 3
• Fiscal Year: 1996

Institution

• Name: University of North Carolina Chapel Hill
• Department: Internal Medicine/Medicine
• Type: Schools of Medicine
• DUNS #: 078861598
• City: Chapel Hill
• State: NC
• Country: United States
• Zip Code: 27599

Publications

Hsia, Hung-Ching; Hutti, Jessica E; Baldwin, Albert S (2017) Cytosolic DNA Promotes Signal Transducer and Activator of Transcription 3 (STAT3) Phosphorylation by TANK-binding Kinase 1 (TBK1) to Restrain STAT3 Activity. J Biol Chem 292:5405-5417

Hsia, Hung-Ching; Stopford, Charles M; Zhang, Zhigang et al. (2017) Signal transducer and activator of transcription 3 (Stat3) regulates host defense and protects mice against herpes simplex virus-1 (HSV-1) infection. J Leukoc Biol 101:1053-1064

Bradford, Jennifer W; Baldwin, Albert S (2014) IKK/nuclear factor-kappaB and oncogenesis: roles in tumor-initiating cells and in the tumor microenvironment. Adv Cancer Res 121:125-145

Dan, Han C; Ebbs, Aaron; Pasparakis, Manolis et al. (2014) Akt-dependent activation of mTORC1 complex involves phosphorylation of mTOR (mammalian target of rapamycin) by I?B kinase ? (IKK?). J Biol Chem 289:25227-40

Kendellen, M F; Bradford, J W; Lawrence, C L et al. (2014) Canonical and non-canonical NF-?B signaling promotes breast cancer tumor-initiating cells. Oncogene 33:1297-305

Stein, Sarah J; Baldwin, Albert S (2013) Deletion of the NF-?B subunit p65/RelA in the hematopoietic compartment leads to defects in hematopoietic stem cell function. Blood 121:5015-24

Hutti, Jessica E; Porter, Melissa A; Cheely, Adam W et al. (2012) Development of a high-throughput assay for identifying inhibitors of TBK1 and IKK?. PLoS One 7:e41494

Awwad, Yousef; Geng, Tao; Baldwin, Albert S et al. (2012) Observing single cell NF-?B dynamics under stimulant concentration gradient. Anal Chem 84:1224-8

Hutti, Jessica E; Pfefferle, Adam D; Russell, Sean C et al. (2012) Oncogenic PI3K mutations lead to NF-ýýB-dependent cytokine expression following growth factor deprivation. Cancer Res 72:3260-9

Comb, William C; Hutti, Jessica E; Cogswell, Patricia et al. (2012) p85ýý SH2 domain phosphorylation by IKK promotes feedback inhibition of PI3K and Akt in response to cellular starvation. Mol Cell 45:719-30