Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
3R01AI035217-04S1
Application #
2070717
Study Section
Special Emphasis Panel (SRC (36))
Project Start
1993-09-30
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Zahrt, Thomas C; Deretic, Vojo (2002) Reactive nitrogen and oxygen intermediates and bacterial defenses: unusual adaptations in Mycobacterium tuberculosis. Antioxid Redox Signal 4:141-59
Zahrt, T C; Deretic, V (2001) Mycobacterium tuberculosis signal transduction system required for persistent infections. Proc Natl Acad Sci U S A 98:12706-11
Fratti, R A; Vergne, I; Chua, J et al. (2000) Regulators of membrane trafficking and Mycobacterium tuberculosis phagosome maturation block. Electrophoresis 21:3378-85
Zahrt, T C; Deretic, V (2000) An essential two-component signal transduction system in Mycobacterium tuberculosis. J Bacteriol 182:3832-8
Deretic, V; Fratti, R A (1999) Mycobacterium tuberculosis phagosome. Mol Microbiol 31:1603-9
Via, L E; Fratti, R A; McFalone, M et al. (1998) Effects of cytokines on mycobacterial phagosome maturation. J Cell Sci 111 ( Pt 7):897-905
Sreevatsan, S; Pan, X; Zhang, Y et al. (1997) Analysis of the oxyR-ahpC region in isoniazid-resistant and -susceptible Mycobacterium tuberculosis complex organisms recovered from diseased humans and animals in diverse localities. Antimicrob Agents Chemother 41:600-6
Via, L E; Deretic, D; Ulmer, R J et al. (1997) Arrest of mycobacterial phagosome maturation is caused by a block in vesicle fusion between stages controlled by rab5 and rab7. J Biol Chem 272:13326-31
Deretic, V; Via, L E; Fratti, R A et al. (1997) Mycobacterial phagosome maturation, rab proteins, and intracellular trafficking. Electrophoresis 18:2542-7
Dhandayuthapani, S; Zhang, Y; Mudd, M H et al. (1996) Oxidative stress response and its role in sensitivity to isoniazid in mycobacteria: characterization and inducibility of ahpC by peroxides in Mycobacterium smegmatis and lack of expression in M. aurum and M. tuberculosis. J Bacteriol 178:3641-9

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